The Application Law Of Traditional Chinese Medicine In The Rehabilitation Of Severe Pneumonia And Network Pharmacology Analysis

1 Summary of the Rule of Drug Use for Severe Pneumonia RehabilitationOBJECTIVE:To explore the syndromic treatment experience and prescription medication rule of severe pneumonia rehabilitation by using the Software-based date mining techniques of Chinese Medicine Inheritance Support Platform(V2.5).METHODS:through the "haitai electronic medical record" system,collected the diagnosis of "severe pneumonia" according to Western medicine,after the treatment to achieve clinical stability,to meet the time conditions for the intervention of respiratory severe rehabilitation standards,in line with the "weakness severe delay”diagnosis of the traditional Chinese medicine.A total of 54 eligible patients were included,85 were hospitalized,170 medical cases were obtained,and 170 prescriptions were obtained.Data entry and data analysis of patients 'basic information,four diagnosis information,clinical symptoms,syndrome classification,treatment rules and specific prescription information are carried out using the Software-based date mining techniques of Chinese Medicine Inheritance Support Platform(V2.5).RESULTS:Basic statistics,with an average age of 80.6 and a ratio of 57:43 men and women;According to the symptom statistics,93 symptoms were obtained,and 19 symptoms appeared over 30 times;Tongue and pulse statistics,a total of 6 tongue,12 tongue coating signs and 9 pulse images;Syndrome statistics,including phlegm fever lung syndrome,lung deficiency and evil love syndrome,phlegm and phlegm obstruction lung syndrome,lung and kidney two deficiency syndrome,heart and lung Qi yin deficiency syndrome,lung Qi yin deficiency syndrome,lung spleen deficiency syndrome,phlegm and dampness lung syndrome;The statistics of the rule of law correspond to a total of 10 kinds of rules and regulations;Prescription and Dialectics were analyzed and obtained a visual network diagram of the drug-disease relationship and the drug-syndrome relationship;Statistics on the frequency of use of drugs,prescriptions include a total of 131 traditional Chinese medicines,over 15 times more than 40 kinds of Chinese medicines;According to the statistics of drug use,the dosage of huangqi was 12-25g,the dosage of haungqin was 10-15g,the dosage of digupi was 10-20g,the dosage of shanyao was 15-25g,and the dosage of fuling was 15-100g;According to drug taste statistics,warm drugs accounted for 41%,cold drugs accounted for 35%,flat drugs accounted for 21%,cold drugs accounted for 2%,hot drugs accounted for 1%,sweet drugs accounted for 44%,bitter drugs accounted for 32%,peppery drugs accounted for 17%.Acid drugs account for 3%,astringent drugs account for 2%,salty drugs account for 2%;According to statistics,18%belong to the channel of spleen,17%to the channel of lung,16%to the channel of stomach,13%to the channel of kidney,11%to the channel of liver,9%to the channel of heart,7%to the channel of large intestine,3%to the channel of gallbladder,2%to the channel of small intestine,2%to the channel of bladder,1%to channel of pericardium,0.1%to the channel of triple Coke;Correlation rule analysis,the number of support is 90,the confidence is 0.9,the core prescription:huangqi,huangqin,digupi,shanyao,gualou;Cluster analysis,correlation is 0.8,punishment is 2 get 26 potential drug combinations,13 new party combinations.CONCLUSION:The treatment of severe pneumonia rehabilitation weakness severe delay)follows the general principle of "virtual compensation",protect healthy qi and eradicate exterior pernicious should be taken into account and the"harmony method"should be used.The core prescription consists of:huangqi,huangqin,digupi,shanyao,and gualou.It reflects the idea that protect healthy qi and eradicate exterior pernicious take into account,Qi and blood double complement,yin and Yang coordination,complement but not delay,but can not be scattered prescription medication.2 The network pharmacological analysis of core drugs in prescriptionOBJECTIVE:To predict the role of core chinese medicine in treatment of severe pneumonia rehabilitation and explore the mechanism of drug action.METHODS:The active ingredients and targets of Chinese medicine were obtained by TCMSP database and the disease targets were obtained by GeneCards database.Taking the target of the intersection of Chinese medicine and disease,the control network of"Chinese medicine-active ingredient-target-disease" was constructed using Cytoscape.Using String database to get PPI network of targets and screen the core action of targets.Analyze the GO function and KEGG pathway of the targets.RESULTS:Targets of Chinese traditional medicine and disease:Huangqi-severe pneumonia 101,Huangqin-severe pneumonia 45,digupi-severe pneumonia 26,shanyao-severe pneumonia 24,gualou-severe pneumonia 5;The main drug components in the "Chinese medicine-Chinese medicine component-target-severe pneumonia" regulatory network,huangqi:Isorhamnetin,Formonetin,Kaempferol.haungqin:Baicalein,Oroxylin A,Acacetin.digupi:Acacetin,Hederagenin.shanyao:Diosgenin.gualou:Diosmetin;The core targets in the PPI network include:PT GS2,AKT1,VEGFA,CASP3,JUN,Rel A,IL-6,CXCL8,MMP9,etc;The main enrichment functions of the target GO are:cytomine binding,cytokine activity,phoxase binding,process cell binding,ubiquitin-technology,ubiquitin process ligase binding,etc;The main KEGG pathway of the target is concentrated:NF-kappa B signaling pathway,HIF-1 signaling pathway,IL-17 signaling pathway,Toll-like rector signaling pathway,C-type rector precession pathway,etc.CONCLUSION:the effective ingredients of huangqi,huangqin,digupi,shanyao,gualou in the core prescription play an important role in the anti-bacterial,anti-inflammatory and antiviral treatment of severe pneumonia.Diastolic bronchial smooth muscle reduces pathological changes in the lung group and acts against cough and phlegm.Adjust immunity,improve patient resistance.It regulates apoptosis and affects metabolism.Antioxidant,free radical removal,repair damaged nerves,improve cognitive and consciousness disorders,enhance the body's motor function.To reduce allergic reactions and adjust gastrointestinal dysfunction.Targets that play a central role in PPI networks are mainly related to infection,immunity,metabolism,and apoptosis.The GO function of the target is mainly to participate in immune response and immune regulation,promote cell growth,and repair tissue damage.Bacterial suppressive,anti-inflammatory,enhance anti-infection ability.Participate in apoptosis,affect cell metabolism,etc;The targets enrich in KEGG pathway is mainly related to bacteria,viral infections,fungal infections,hypoxia reactions,and immune regulation.It is aimed at the low immunity,multiple drug-resistant infections,and respiratory failure in the rehabilitation of severe pneumonia.