| Background:With the development of social science and technology,the improvement of living conditions and the change of lifestyle,the incidence of polycystic ovary syndrome is also increasing year by year,bringing a series of family and social stress to women of childbearing age,which seriously affects people’s lives.quality.The disease has the characteristics of etiology,heterogeneity of clinical manifestations and dysfunction of disease course,and it is a hot and difficult problem in the field of gynecology.Purposes:Based on the theory of KeNang,the clinical efficacy of Xuefu Zhuyu Decoction in the treatment of phlegm and blood stasis polycystic ovary syndrome was discussed.Starting from the ancient books of traditional Chinese medicine,based on the theory of KeNang,it aims to explore ways to treat PCOS.Methods:This study was a randomized case-control trial.Patients were randomized into a Chinese medicine treatment group and a Western medicine control group according to the inclusion criteria.The control group was treated with Da Ying-35.The treatment group was treated with Xuefu Zhuyu Decoction for 3 months.The menstrual and ovulation status of patients before and after treatment,clinical symptoms,sex hormone levels,body mass index(BMI),and fasting were recorded.Blood glucose(FPG),fasting insulin(FINS),changes in bilateral ovarian volume under B-ultrasound,calculation of insulin resistance index(HOMA-IR)and ovarian volume,the results were statistically processed and analyzed to determine its Clinical efficacy.Results:A total of 52 eligible subjects were enrolled in this study.They were randomly divided into a treatment group of 26 patients and a control group of 26 patients.No adverse reactions were seen before and after treatment.(1)General data(age,duration),TCM syndrome score,menstrual score,T,LH/FSH,ovarian volume,BMI,FINS,FPG,HOMA-IR were statistically analyzed before treatment.P<0.05,the difference was not statistically significant and these data are clinically comparable.(2)After treatment,the clinical efficacy of the treatment group was 80.8%,and the clinical efficacy of the control group was 76.9%.After statistical analysis,P<0.05,the difference was not statistically significant,indicating that there was no significant difference in clinical efficacy between the two groups.The pregnancy of the patient after the end of treatment indicates that the treatment group has a good effect in improving the pregnancy rate of the patient.Before and after treatment,the TCM syndrome scores of the treatment group and the control group were compared,P<0.05,the difference was statistically significant,indicating that both groups can improve the clinical symptoms of TCM patients;after treatment,the TCM syndrome scores of the treatment group and the control group were compared,P<0.05,the difference was statistically significant.Results 2 can be seen that the treatment group improved the TCM syndrome scores of patients better than the control group.Before and after treatment,the menstrual scores of the treatment group and the control group were compared,P<0.05,9 and the difference was statistically significant,indicating that both groups can improve the menstrual status of the patients.After treatment,the menstrual scores of the treatment group and the control group were compared,P>0.05,indicating that there was no significant difference in the efficacy of menstruation between the two groups.(3)The levels of serum T and LH/FSH in the treatment group and the control group before and after treatment were compared,P<0.05,the difference was statistically significant,indicating that both groups can reduce the serum T and LH/FSH levels of the patients;The serum T of the control group was compared,P<0.05,the difference was statistically significant.As can be seen from Fig.4,the effect of lowering serum T in the control group was better than that in the treatment group;the serum LH/FSH in the treatment group and the control group after treatment,P>0.05 The difference was not statistically significant,indicating that there was no significant difference in the efficacy of the two groups in improving serum LH/FSH.Before and after treatment,the ovarian volume of the treatment group and the control group were compared,P<0.05.The difference was statistically significant,indicating that both groups could reduce the ovarian volume of PCOS patients.After treatment,the ovarian volume of the treatment group and the control group were compared,P<0.05.Statistically significant,there was no significant difference in efficacy between the two groups in reducing ovarian volume in patients with PCOS.Before and after treatment,the BMI of the treatment group and the control group were compared,P<0.05,the difference was statistically significant,indicating that both groups could reduce the BMI level of the patients.After treatment,the BMI of the treatment group and the control group were compared,P>0.05,the difference was not statistically significant,indicating that there is no significant difference in the efficacy of the two groups in improving the BMI of patients.FINS,FPG and HOMA-IR were compared between the control group and the treatment group before and after treatment.Among them,the results of FINS and HOMA-IR were P<0.05,the difference was statistically significant,and the FPG data structure weas P>0.05.The difference was not statistically significant.The group can reduce the levels of FINS and HOMA-IR in patients with PCOS,5and has no obvious effect in reducing serum FPG After treatment,the FINS,FPG and HOMA-IR of the two groups"were compared,P>0.05,the difference was not statistically significant,indicating that there was no significant difference between the treatment group and the control group in reducing the effect of HOMA-IR in PCOS patients,and mainly by lowering the serum FINS level.Improve patient insulin resistance.Conclusion:The theory of KeNang is safe and effective in guiding the treatment of patients with phlegm and blood stasis type PCOS.It is equivalent to the clinical efficacy of Ethinylestradiol and Cyproterone Acetate Tablets.Traditional Chinese medicine has an outstanding effect in improving the clinical symptoms of PCOS patients,and does not affect the patient’s pregnancy during the medication,but the efficacy in reducing serum androgen levels is worse than Ethinylestradiol and Cyproterone Acetate Tablets.The treatment of PCOS with the theory of KeNang has a broad prospect.It is recommended that in the treatment of polycystic ovary syndrome,combined with the clinical symptoms,indicators and appeals of patients,there is a choice of traditional Chinese medicine or combination of traditional Chinese and Western medicine.However,further research is needed to confirm and promote clinical practice. |
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