Research On The Control Method Of Multi-compartment Pressure Difference In Biopharmaceutical Plant

With the rapid development of China’s clean production demand,the number and scale of pharmaceutical cleanrooms have increased rapidly.Due to the high cleanliness requirements of the cleanroom,the cleanliness requirements are different in different areas of the pharmaceutical cleanroom.To prevent cross-contamination of the air environment in different levels of clean areas,the differential pressure control in the clean room is especially critical.A major difficulty and important research direction in the technical fieldThis paper will take the pharmaceutical clean workshop as the main research object.Through consulting a large number of domestic and foreign literatures,field research,analyze the current pressure difference control of pharmaceutical plants,and design and establish a multi-compartment differential pressure control laboratory.The purpose is to restore the real plant to the greatest extent,so that the control effects of different control algorithms under different disturbances can be tested on the experimental platform.In the actual investigation of a pharmaceutical factory,through the measurement and numerical analysis method,the relationship between the residual air volume and the pressure difference--the quadratic relationship is obtained.Therefore,we can control the differential pressure by detecting the residual air volume later.In the pharmaceutical cleanroom,the reasonable control system for pressure difference control can not only quickly and efficiently respond,reduce air redundancy and save energy,but also better protect environmental parameters in the case of disturbance.This article carrying out the mathematical modeling of typical cleanroom,using Simulink as a simulation research tool to set up three common,typical internal pressure relief situation in the cleanroom(firstly,controlled object door disturbance;secondly,corridor door disturbance;thirdly,effects of disturbed rooms on others),using auto-disturbance-rejection control algorithm for pressure control in cleanroom,and finally analyzing and evaluating the simulation results to put forwards the feasibility of auto-disturbance-rejection control in cleanroom air environment control.Modeling two types of rooms with different sizes in the clean laboratory of this project,using Airpak simulation software to simulate two typical airflow organization forms under Class B cleanliness,namely,the top-side and side-side back,and the large room.The influencing factor of the introduction of the orifice plate is used to analyze the uniformity of the airflow in the mainstream working area.The results show that the top-side lower back is selected as the airflow organization of the small room,while the large room is limited by height and considering the space reserved by the FFU.In the form of the inner side of the orifice sandwich...