Portable Melt Electrospinning Device And Its Application Research In The Field Of In-situ Biomedicine

Electrospinning has been extensively explored as a simple,versatile,and cost-effective method in preparing ultrathin fibers from a wide variety of materials.Electrospun ultrathin fibers are now widely used in tissue scaffold,wound dressing,energy harvesting and storage,environment engineering,catalyst and textile.Typically,electrospun nanofibres have a high porosity with excellent pore-interconnectivity,which is particularly important for wound healing.The goal of this work is to develop the biomedical applications of in-situ electrospinning and review the current status of the industrialization of electrospinning technology.The research contents are included as follows:?1?Electrospun?e-spun?nanofibers for wound dressing have attracted wide attention due to its large specific surface area,large porosity and breathability.Compared with solution electrospinning?e-spinning?,melt e-spinning is more bio-friendly without toxic solvent participation,which provides the possibility of in situ e-spinning on wounds directly.However,previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit,and different components were separated to avoid electrostatic interference.In this article,we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply?outdoors?.The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit.The apparatus is easy and safe to operate by a single hand due to its small volume?24×6×13 cm³?and light weight?about 450 g?.Some biodegradable polymers,for example,polycaprolactone?PCL?fibers were successful e-spun onto wounds directly by using this dressing gun.Besides wound dressing,this hand-held melt e-spinning gun may be used in3D printing and experimental teaching demonstration aids.?2?Magnetic fibrous membrane used to generate heat under the alternating magnetic field?AMF?has attracted wide attention due to their application in magnetic hyperthermia.However,there is not magnetic fibrous membrane prepared by melt electrospinning?e-spinning?which is a solvent-free,bio-friendly technology.In this work,polycaprolactone?PCL?/Fe₃O₄ fiber membrane was prepared by melt e-spinning and using homemade self-powered portable melt e-spinning apparatus.The polycaprolactone/Fe₃O₄ composite fibers with diameters of 4-17?m,are very uniform.In addition,the magnetic composite fiber membrane has excellent heating efficiency and thermal cycling characteristics.The results indicated that self-powered portable melt e-spinning apparatus and PCL/Fe₃O₄ fiber membrane may provide an attractive way for hyperthermia therapy.?3?Solvent recovery is a big challenge for conventional solution electrospinning for large-scale production of ultrafine fibers because the precursor utilization ratio is usually less than 20 wt%.In this paper,we report an eco-friendly two-component electrospinning for fabrication of acrylate composite fibers by a homemade device at room temperature.During this electrospinning process,the two-component spinning solutions are nearly all electrospun into ultrafine fibers,and the utilization ratio of precursor can reach more than 90 wt%.The fiber solidification mechanism can be ascribed to rapid polymerization of IBOMA monomer in the presence of free radicals formed by a redox initiation system?BPOEH+DMA?,which is different from the solvent evaporation in solution electrospinning or cooling solidification in melt electrospinning.Such a two-component electrospinning technology may give some stimulation for developing eco-friendly approach to fabricate composite and functional ultrafine fibers.