Asymmetric Trost Reaction And Structural Modification Of Gentiopicroside In β-lactam Spirocyclic Compounds

This thesis consists of two chapters,including the asymmetric Trost reaction of β-lactams and the structural modification of gentiopicroside.Asymmetric Trost reactions of β-lactam compounds were studied.Since the discovery of penicillin,as the main antibacterial drugs in the world,beta lactam compounds have attracted much attention.Due to the mainly and continuely using,β-lactam drugs have a ever-increasing problem of drug resistance.Therefore,it is particularly important to explore the development of new β-lactam compounds.In our group,the study of P-lactam compounds mainly focused on the synthesis of diastereoisomers and the asymmetric synthesis.Therefore,this thesis application of iodobenzene diacetate(IBD)oxidative decarbonylation to construct β-lactam ring,and then used Trost reaction to build chiral spiro.Studies on the structural modification of gentiopicroside were carried out.Gentiopicroside has the effects of protect liver injuey,clearing gallbladder,clearing heat and relieving spasm.Because of its rapid metabolism in the body,results in lower oral bioavailability.In view of its good biological activity and pharmacological activity,which make it has the potential prospect of medicinal development,so it is very important to carry out the structural modification and explore the further research value.This paper used the Olefin metathesis reaction and Suzuki coupling reaction to modify the structrue of gentiopicroside and 23 new gentiopicroside products were obtained successfully.