| Object ive1.To explore the difference of clinical efficacy of“Tiaoshen Kaiqiao" acupuncture therapy and fluoxetine hydrochloride in patients with ischemic post-stroke depression;2.By comparing the levels of blood lipid metabolites before and after treatment in patients with ischemic post-stroke depression,the possible mechanism of acupuncture treatment for ischemic post-stroke depression was discussed.Methods107 patients with post-ischemic stroke depression were randomly divided into the expe-rimental group(n=51)and the control group(n=56).Patients in both groups were treated with conventional treatment of ischemic stroke.On this basis,the experimental group was treated with“Tiaoshen Kaiqiao" acupuncture therapy combined with oral placebo,while the control group was treated with sham acupuncture therapy combined with fluoxetine hydrochloride.Before and after 12 weeks of treatment,Scale evaluators assessed the Hamilton Depression scale-17(HAMD-17)and National Institute of Health Stroke Scale(NIHSS)one by one.The subjects received routine biochemical tests before and 12 weeks after treatment to observe the changes in total cholesterol(TC),Triglyceride(TG),low-density lipoprotein(LDL)and high-density lipoprotein(HDL)levels.Collate the data and make statistical analysis to get the result.results1.General dataThe baseline data of the two groups in this study were statistically analyzed in terms of gender,age,height,weight and duration of depression,and the differences were not statistically significant(P>0.05),indicating that the two groups were comparable.2.Total clinical efficiencyAfter 12 weeks treatment,12 cases in the experimental group showed significant effe-ct,13 cases were effective,16 cases were improved,10 cases were ineffective,and the total effective rate was 80.39%;11 cases in the control group showed significant effect,12 cases were effective,13 cases were improved,20 cases were ineffective,and the total effective rate was 64.28%.The results showed that the therapeutic effect of the two groups was similar(P>0.05).3.Comparison in scale score(1)Results of HAMD-17 scale:after the 12th week,the scores of the two groups were compared,and the difference was not statistically significant(P>0.05).In addition,the scores of the two groups decreased compared with the baseline,and the differences were statistically significant(P<0.01),indicating that both treatments could improve the moderate and mild depressive symptoms of PSD patients.By comparing the sleep and gastrointestinal scores in the scale separately,it was found that there was a statistically significant difference between the experimental group and the control group in the improvement of the above symptoms(P<0.05).(2)Comparison results of depression degree of PSD patients after treatment:different treatment methods in the experimental group and the control group could improve the depression degree of PSD patients to different degrees,and there was no statistically significant difference(P>0.05)between the groups,indicating that both treatment methods could positively regulate the depression degree of PSD patients.(3)Comparison of scores of NIHSS scale:after the 12th week,the scores of the experimental group and the control group were compared and analyzed,and the difference was not statistically significant(P>0.05).Compared with the baseline,the scores of the experimental group and the control group were lower to a certain extent,and the differences were statistically significant(P<0.01).Based on this result,it was suggested that the corresponding treatment methods in the two groups could improve the neurological defects of PSD patients.4.Blood related lipid metabolism index(1)Comparison of TC content before and after treatment in two groups of PSD patients after 12 weeks,the TC content of PSD patients in the test group was lower than that in the control group,but the difference was not statistically significant(P>0.05).The TC content of the two groups decreased from the baseline level,and the difference was not statistically significant(P>0.05).Based on the results of this experiment,it was shown that the TC content of patients in both groups did not fluctuate significantly(2)Comparison of TG detection results between the two groups of PSD patients before and after treatment:after 12 weeks,the TC detection results of the experimental group and the control group were analyzed,and it was found that the TG content of the experim ental group was lower than that of the control group,but the difference was not statistically significant(P>0.05).The TG content of the two groups was lower than that at baseline,and the difference was statistically significant(P<0.05).Therefore,the two treatment methods used in this experiment can reduce the TG content of patients.(3)Comparison of LDL content before and after treatment in the two groups of PSD patients:after 12 weeks,the LDL content of the two groups was compared and analyzed,and it was concluded that the LDL content of the experimental group was lower than that of the control group,but the difference was not statistically significant(P>0.05).When the two groups were compared before and after treatment,it was found that the LDL content in the experimental group was lower than the baseline level,and the difference was statistically significant(P<0.05).The LDL content in the control group decreased from the baseline level,but the difference was not statistically significant(P>0.05).(4)Comparison of HDL content before and after treatment in the two groups of PSD patients:after 12 weeks,analysis of the test results showed that the HDL content of the test group was lower than that of the control group,but the difference was not statistically significant(P>0.05).Moreover,the HDL content of patients in the test group and the control group increased compared with the baseline level,and the difference was statistically significant(P<0.05).Conolusion1.Based on the study of small samples,the clinical efficacy of "Tiaoshen Kaiqiao" acupun-cture therapy in the treatment of PSD is positive and worth promoting.2.The therapeutic effect of "Tiaoshen Kaiqiao" acupuncture therapy is similar to that of fluoxetine hydrochloride in the treatment of PSD,both of which can improve the symptoms of depression and neurological defects in patients.However,“Tiaoshen Kaiqiao" acupuncture therapy can improve the sleep and gastrointestinal symptoms of PSD patients due to fluoxetine hydrochloride.3.The "Tiaoshen Kaiqiao" acupuncture therapy can significantly improve the serum levels of TG,LDL and HDL in patients with post-ischemic stroke depression,but has no significant effect on TC.It is preliminarily speculated that the benign regulation of TG,LDL and HDL levels by "Tiaoshen Kaiqiao" acupuncture therapy is the possible mechanism for the treatment of PSD. |
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