| Objective: Metal elements enter the human body through a variety of ways and have a variety of health effects on the human body.Previous studies have shown that the exposure of lead,cadmium,molybdenum and other metals is related to the occurrence and development of hyperuricemia,but so far there are few reports on the relationship between polymetallic elements and the risk of hyperuricemia.Because the human body is often exposed to a variety of metals at the same time in daily life,and there is interaction between metals.Therefore,it is necessary to study the health effects of multiple metals acting on the body at the same time.Taking this as a starting point,this study explored the relationship between plasma metal concentrations and the risk of hyperuricemia.Methods: In this study,people who received routine physical examination in the eighth affiliated Hospital of Sun Yat-sen University were selected as subjects.Hyperuricemia and control population were matched according to the proportion of age and sex at 1:2,including 303 hyperuricemia and 606 control population.The contents of 11 metals(aluminum,arsenic,cadmium,cobalt,copper,iron,manganese,molybdenum,selenium,thallium and zinc)in plasma were determined by ICP-MS.Student's t test,rank sum test or chi-square test were used to compare the basic characteristics of the population and the difference of plasma metal concentration.The correlation among plasma metal concentrations was analyzed by Spearman rank sum correlation.In the single metal model,Logistic regression was used to explore the relationship between plasma metal exposure and the risk of hyperuricemia,and principal component analysis was used to explore the relationship between polymetallic principal components and hyperuricemia.Results: In this study,the average age of the case group was 60.16-7.62 years old,and the average age of the control group was 60.05-7.44 years old,the difference was not statistically significant(paired 0.839).In the case group,118(38.94%)were males and 185(61.06%)were females.The BMI of the case group was 24.76 ±2.63,while that of the control group was 23.40 ±2.62,the difference was statistically significant(p < 0.001).There was no significant difference in the number of smokers and drinkers between the case group and the control group(smoking: 12.29% and 11.24% dope 0.643;drinking: 12.37% and 9.38% dope 0.166).The proportion of hypertension in the case group was higher than that in the control group(38.94% and 28.05%),but there was no significant difference in the proportion of diabetes between the two groups(10.56% and 8.75%).0.376).There were differences in triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)between the two groups.Among them,the TG,TC and LDL-C in the case group were higher than those in the control group(1.94 ±1.29,1.44 ±0.90)(p < 0.001 × 5.60 ±1.14,5.42 ±1.10),while the HDL-C in the case group was lower than that in the control group(1.38 ±0.49 and 1.46 ±0.38).Plasma creatinine(Cre)in the case group was significantly higher than that in the control group(77.39 ±28.69,68.85 ±15.81 P < 0.001).The results of Logistic regression analysis showed that after adjusting for age,sex,BMI,smoking and drinking,the concentration of plasma As,Se and Tl had a dose-response relationship with the increased risk of hyperuricemia(P-trend < 0.05).Subjects with As levels in the fourth quartile had a 2.22 times higher risk of hyperuricemia than those in the first quartile(patients with 95%CI:1.45~3.42);Se levels in the third quartile had a 1.83 times higher risk of hyperuricemia than those in the first quartile(95%CI:1.19~2.81),and those in the fourth quartile had a 1.57 times higher risk of developing hyperuricemia than those in the first quartile(95%CI:1.02~2.43).Subjects with Tl levels in the fourth quartile had a 1.57 times higher risk of hyperuricemia than those in the first quartile(95%CI:1.04~2.37),while high Mo levels had a protective effect on the risk of hyperuricemia,with subjects with Mo levels in the second quartile having a 0.64 times higher risk of hyperuricemia than those in the first quartile(95%CI:0.42~0.96).After further adjustment for hypertension,diabetes,TG,TC,LDL-C,HDL-C,Cre,As and Tl were still found to have a dose-response relationship with the increased risk of hyperuricemia(P-trend < 0.05).Subjects with As levels in the fourth quartile had a 2.24 times higher risk of hyperuricemia than those in the first quartile(subjects with 95%CI:1.40~3.57);Tl levels in the fourth quartile had a 1.58 times higher risk of developing hyperuricemia than those in the first quartile(95%CI:1.02~2.44).Subjects in the third quartile of Se had a 1.80 times higher risk of developing hyperuricemia than those in the first quartile(95%CI:0.37~0.90).(subjects in the second quartile of 95%CI:1.14~2.85);Mo had a 0.58 times higher risk of developing hyperuricemia than those in the first quartile(95%CI:0.37~0.90).After dimension reduction of 11 metal elements by principal component analysis,it was found that component 4,which mainly represents As,was positively correlated with the risk of hyperuricemia.After adjusting for age,sex,BMI,smoking and drinking,component 4 showed a significant dose-response relationship with the risk of hyperuricemia(p-trend < 0.05).Among them,the risk of hyperuricemia of subjects in the third quartile of component 4 was 1.76 times higher than that of the first quartile(95%CI:1.08~2.86),and the risk of hyperuricemia of subjects in the fourth quartile was 2.59 times higher than that of the first quartile(95%CI:1.62~4.12).After further adjustment for hypertension,diabetes,TG,TC,HDLC,LDL-C and Cre,component 4 still had a significant dose-response relationship with the risk of hyperuricemia(p-trend < 0.05).Among them,the risk of hyperuricemia in the 2nd,3rd and 4th quartile of component 4 was 1.76 times(95%CI:1.04~2.99),1.84 times(95%CI:1.09~3.12)and 2.82 times(95%CI:1.71~4.67)of the first quartile,respectively.Conclusion: In this study,it was found that the internal exposure levels of metal elements such as As,Se and Tl were positively correlated with the risk of hyperuricemia and were the risk factors of hyperuricemia,while the element Mo was negatively correlated with the risk of hyperuricemia and was the protective factor of hyperuricemia.It was also found that there was a dose-response relationship between the plasma contents of As,Se,Tl and the risk of hyperuricemia(P-trend < 0.05).However,the combined effect of multiple metal exposures on hyperuricemia was not found. |
PDF Full Text Request