Association Of Plasma Selenium Levels And Fatty Liver Disease

Objective:To explore the association of plasma selenium levels with FLD and NAFLD.Methods:This study was a case-control study.Participants were consecutively recruited from patients attending Egang hospital in Ezhou(Hubei,China).Patients diagnosed with FLD by ultrasonography were enrolled into case group,the remaining non-FLD patients who met the inclusion criteria were enrolled into control group.Based on FLD group,NAFLD case group was screened according to NAFLD diagnostic criteria,moreover,control group matched by age and gender was selected from non-NAFLD participants.Data was collected by questionnaire and physical examination.Blood samples were collected and plasma selenium concentrations were measured by ICP-MS.Logistic regression analysis was conducted to evaluate association of plasma selenium levels between FLD and NAFLD.Results:1.Association of plasma selenium levels and FLD:1538 subjects were included in this part of study,546 were FLD cases and 992 were controls.Compared with controls,FLD cases had significantly higher plasma selenium levels(98.36 vs.95.58 ?g/L,P<0.001).Stratifying plasma selenium levels into tertiles,Compared with FLD cases at lowest tertile of plasma selenium levels(<89.94 ?g/L),the odds ratio of FLD cases at highest tertile of plasma selenium levels(? 103.28 ?g/L)was 1.65(95%CI,1.27-2.13)(P<0.01).Then we treated plasma selenium levels as continuous variable,for every 10?g/L increment of plasma selenium concentration,the odds ratio of FLD was 1.09(95%,1.04-1.15)(P<0.01),and the linear dose-response trend was significant(P<0.001).After adjustment for age,sex,BMI,current smoking status,current drinking status,hypertension and family history of diabetes,the association still existed,for every 10?g/L increment of plasma selenium concentration,the odds ratio of FLD was 1.10(95%CI:1.04-1.16)(P<0.001).Moreover,the association still existed in most sub group analysis(except for ? 60y,current smoking,current drinking,family history of diabetes).2.Association of plasma selenium levels and NAFLD:867 subjects were included in this part of study,317 were NAFLD cases and 550 were controls.Compared with controls,NAFLD cases had significantly higher plasma selenium levels(98.03 vs.95.31?g/L,P<0.05).Stratifying plasma selenium levels into tertiles.Compared with NAFLD cases at lowest tertile of plasma selenium levels(<90.21 ?g/L),the odds ratio of NAFLD cases at highest tertile of plasma selenium levels(? 102.63 ?g/L)was 1.75(95%CI,1.24-2.47)(P<0.01).Then we treated plasma selenium levels as continuous variable,for every 10 ?g/L increment of plasma selenium concentration,the odds ratio of NAFLD was 1.09(95%CI,1.02-1.17)(P<0.01),and the linear dose-response trend was significant(P<0.001).After adjustment for age,sex,BMI,current smoking status,current drinking status,hypertension and family history of diabetes,the association still existed,for every 10 ?g/L increment of plasma selenium concentration,the odds ratio of NAFLD was 1.14(95%CI:1.05-1.24)(P<0.01).Moreover,the association still existed in most sub group analysis(except for ? 60y,current smoking,current drinking,rare physical activity,hypertension,family history of diabetes).Conclusions:At high plasma selenium level(>103 ?g/L),elevated plasma selenium levels are associated with higher prevalence of FLD and NAFLD;for every 10 ?g/L increment of plasma selenium concentration,the risk of FLD and NAFLD increase by 10%and 14%,respectively.