Analysis Of Related Factors And Distribution Of TCM Syndromes In Patients With End-stage Kidney Disease With Nonthyroid Illness Syndrome

Objective: To study the general information of chronic kidney disease(CKD)stage 5patients,laboratory indicators,Glomerular filtration rate(GFR),etc.and nonthyroid illness syndrome(Nonthyroid illness syndrome,NTIS),to explore the impact of ESRD patients combined with NTIS on the degree of anemia,lipid metabolism,calcium and phosphorus metabolism etc.,and analyze the distribution of TCM syndromes,syndromes and thyroid Research on the correlation of hormone levels is aimed at providing a theoretical basis for the combination of traditional Chinese and Western medicine,thereby improving the prognosis of patients and improving the quality of life of patients.Methods: A total of 124 patients with CKD stage 5 nondialysis who were hospitalized in the Department of Nephrology,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 1,2019 to November 30,2019 were collected.Record the patient's basic information and relevant laboratory indexes,and use the four-diagnosis and TCM diagnosis to classify the patients.The data will be established into a database,and the data will be statistically analyzed using SPSS23.0 software.Result:1.The primary cause of 124 cases of CKD5 patients with diabetic nephropathy is the largest proportion,43.5%,chronic glomerulonephritis is 14.5%,and hypertension renal damage is 11.3%.2.NTIS group is higher than non-NTIS group in age,Scr,BUN,24 h urine protein quantification,TC,TG,LDL-C,HCY is higher,weight,BMI,FT3,TT3,TT4,GFR,ALB,Hb,HCT Low,P<0.05,the difference is statistically significant.There was no significant difference in TSH,FT4,UA,HDL-C,Ca,P,PTH between the two groups.3.In patients with CKD5,FT3 levels are positively correlated with body weight,BMI,TT4,ALB,Hb,HCT,GFR,and negatively correlated with TG,LDL-C,Scr,24-hour urine protein quantification,TC,HCY and other laboratory indicators,Which is moderately positively correlated with ALB and moderately negatively correlated with HCY;its TT3 level is positively correlated with body weight,BMI,ALB,Hb,HCT,GFR,and P,Scr,BUN,24-hour urine protein quantification,TC,HCY showed a negative correlation,moderatelypositive correlation with ALB,Hb,HCT,GFR,and moderately negative correlation with Scr,HCY.4.In patients with stage 5 CKD,increased age,HCY,and decreased TT4,GFR,and ALB are risk factors for inducing NTIS,increased HCY and decreased ALB are risk factors for low FT3,and increased BUN,HCY,and ALB are induced Risk factors for low TT3.5.Among the 124 patients with stage 5 CKD,this deficiency syndrome is most common in patients with spleen and kidney yang deficiency syndrome,followed by spleen and kidney yang deficiency syndrome,and yin and yang deficiency syndrome;standard evidence is blood stasis syndrome,which is most common,followed by wet turbidity syndrome With a drug addiction certificate.6.The incidence of NTIS in this deficiency syndrome is related to the distribution of syndrome types.From high to low,there are spleen and kidney yang deficiency syndrome,yin and yang deficiency syndrome,spleen and kidney qi deficiency syndrome,qi and yin deficiency syndrome,liver and kidney yin deficiency syndrome.Among them,the incidence of NTIS in spleen and kidney yang deficiency syndrome and yin and yang deficiency syndrome is significantly higher than that of spleen and kidney qi deficiency syndrome and qi and yin deficiency syndrome;the incidence of low FT3 in spleen and kidney yang deficiency syndrome is significantly higher than that of spleen and kidney qi deficiency syndrome,The incidence of low FT3 in Yin-Yang deficiency syndrome was significantly higher than that of spleen-kidney deficiency syndrome;the incidence of low TT3 in Spleen-Kidney Yang deficiency syndrome and Yin-Yang deficiency syndrome was significantly higher than that of spleen-kidney deficiency syndrome and Qi-yin deficiency syndrome,P< 0.05,the difference is statistically significant.There is no obvious correlation between the distribution of standard empirical evidence and the incidence of NTIS.7.The levels of FT3 and TT3 in this deficiency syndrome are related to the distribution of syndrome types.The levels of FT3 and TT3 in the syndromes of yin and yang deficiency and spleen and kidney yang deficiency are significantly lower than the syndromes of spleen and kidney qi deficiency,liver and kidney yin deficiency,and qi and yin.False syndrome,P<0.05,the difference was statistically significant.There is no obvious correlation between the level of thyroid hormone and the distribution of syndrome type in the standard empiricalevidence.Conclusions:1.The incidence of NTIS in non-dialysis patients with stage 5 CKD continues to increase as renal function declines,and increases with age.The occurrence of NTIS is related to low metabolic state,high toxin state,anemia state,hypoproteinemia,hyperlipidemia,and hyperhomocysteinemia.2.In patients with CKD5,the decrease of FT3 level is related to the reduction of body weight,BMI,TT4,ALB,Hb,HCT,and GFR,and it is related to the increase of TG,LDL-C,Scr,24-hour urine protein quantification,TC,and HCY;their TT3 Decreased levels are associated with decreased body weight,BMI,ALB,Hb,HCT,GFR,and P,Scr,BUN,24-hour urine protein quantification,TC,HCY increased.3.Among CKD5 patients,age,TT4,GFR,ALB and HCY are the risk factors for inducing NTIS;ALB and HCY are the risk factors for inducing low FT3;BUN,ALB and HCY are the risk factors for inducing low TT3.4.In the CKD5 patients,the incidence of NTIS and low FT3 and TT3 is higher in the classification of spleen and kidney yang deficiency syndrome and yin and yang deficiency syndrome,and the levels of FT3 and TT3 are lower.