Observation Of The Effect Of Full Process Disease Management Mode On Depression

ObjectiveThe full process disease management is implemented on the basis of conventional treatment for patients with depression,and the effect of the full process disease management mode on the treatment effect of patients is observed to find a more effective management mode for patients with depression.MethodsA total of 70 patients with depression who were hospitalized in the department of rehabilitation psychology of the first affiliated hospital of shihezi university medical college from November 2018 to June 2019 were collected,According to the random number table method,the patients were divided into the whole course management group and the control group,with 35 cases in each group.Patients in the full process disease management group were enrolled and received routine treatment while thefull process disease management service was implemented.Using enzyme linked immunosorbent assay(ELISA)to detect single amine neurotransmitter metabolites in 2 days,4 weeks,8 weeks,16 weeks.Including 5-hydroxyindoleacetic acid(5-HIAA),homovanillic acid(HVA),3-methoxy-4-hydroxyphenylgycol(MHPG,)and evaluate Hamilton depression rating scale(HAMD,24items)scores.The Morisky medication compliance scale(MMSA)and the simplified coping style questionnaire(SCSQ)were assessed at 4weeks,8weeks,16 weeks.Patients in the control group were enrolled and received routine treatment,and at the same time points as those in the full process disease management group,they were evaluated with relevant scales and detected with metabolites of monoamine neurotransmitters.Results(1)Analysis of demographic data: there was no statistically significant difference between the two groups in terms of gender,age,education,and marital status.(P>0.05).(2)Depression evaluation comparison: HAMD scores point effect in both groups was statistically significant(P<0.05),patients with HAMD score will appear as the point significant change,group effect was statistically significant(P<0.05),grouping different can significantly affect patient HAMD scores,a significant interaction effect between point and group(P<0.05),patients with HAMD scores point trends at any time will be different because of the management way is not the same.HAMD score in the full process disease management group decreased gradually from 0 to 4 weeks to 8 weeks and stabilized gradually from 8 to 16 weeks;HAMD score in the control group decreased from 0 to 4 weeks and stabilized gradually from 4 to 8 weeks,and significantly increased from 8 to 16 weeks,there was no statistically significant difference in HAMD scores between the two groups at week 0 and 4(P>0.05),the HAMD scores of the 8 and 16 weeks full process disease management group and the control group were statistically significant(P<0.05).(3)Concentrations of metabolites of monoamine neurotransmitters: The time-point effect of 5-HIAA concentration in the two groups was statistically significant(P<0.05),concentration of 5-HIAA varies significantly with time,grouping effect was statistically significant(P<0.05),different treatments can significantly affect the concentration of 5-HIAA in patients,there is significant interaction between the time point and the grouping(P<0.05),variation trend of 5-HIAA concentration in patients with different time points varies with different management methods,5-HIAA concentration in the full process disease management group increased gradually from 0 weeks to 4 weeks to 8 weeks to 16 weeks,while the 5-HIAA concentration in the control group increased gradually from 0 weeks to 4 weeks and became stable from 4 weeks to 8 weeks to 16 weeks.There was no statistical significance between the concentrations of 5-HIAA at 0,4,and 8 weeks(P>0.05),concentration of 5-HIAA in the 16 th week full process disease management group was higher than that in the control group,and the difference was statistically significant(P<0.05);The time point effect of HVA concentration was not statistically significant(P>0.05),and the grouping effect was not statistically significant(P>0.05).There was no mutual effect between the time point and the grouping(P>0.05).The time point effect of MHPG concentration was not statistically significant(P>0.05),the grouping effect was not statistically significant(P>0.05),and there was no mutual effect between the time point and the grouping(P>0.05).(4)Patient compliance:The proportion of good and bad compliance at week 8 was not statistically significant(P>0.05),and the proportion of good and bad compliance at week 16 was statistically significant(P<0.05).(5)Patient coping style:There was no statistical significance in the proportion of positive coping and negative coping at week 8(P>0.05),and the proportion of positive coping and negative coping at week 16(P<0.05).(6)HAMD score reduction rate: The score reduction rate of the full process disease management group was effective at 4 weeks,8 weeks,and 16 weeks,and the control group was effective at 4 weeks.ConclusionThe full process disease management model can reduce the depressive symptoms of patients with depressive disorder,improve the compliance of patients,and consolidate the treatment effect on the basis of conventional treatment.