Effects Of Silicone Oil On Ganglion Cells And Visual Function In Patients With Rhegmatogenous Retinal Detachment

Objective: Observe the effect of silicone oil on ganglion cell layer(GCL)and visual function in patients with rhegmatogenous retinal detachment(RRD).Through this study,to improve the understanding of clinical fundus disease in the same path on the effect of silicone oil on ganglion cells and visual function in RRD patients,the main significance is to find the basis for silicone oil-related visual acuity decline;The impact of visual function.Methods: The patients who were diagnosed with RRD in macular area and diagnosed as vitrectomy in Shihezi University First Affiliated Hospital from January 2018 to January 2019 were collected and divided into observation group(silicone oil filled group)and control group.(Gas-filled group)In 20 cases,both groups received vitrectomy.The observation group was given silicone oil injection into the vitreous cavity,and the control group was given sterile nitrogen injection into the vitreous cavity,all before,1 week and 1postoperatively,3,6 months to detect the best corrected visual acuity(BCVA)of the two groups of patients,and use optical coherence tomography(optical coherence tomography-OCT)to detect and compare the GCL thickness of the two groups.Results: Compared with preoperative visual acuity at 1 week after operation,visual acuity slightly increased in the two groups,but the difference was not statistically significant,P> 0.05(observation group:P = 0.844;control group: P = 0.618);two groups after 1 month Visual acuity compared with preoperative(observation group: P = 0.038;control group: P = 0.031)and one week after operation(observation group:P = 0.042;control group: P = 0.033)were significantly improved,the difference was statistically significant,P <0.05;the visual acuity of the observation group at 6 months after operation was compared with that before operation(P = 0.053)and 1 week after operation(P = 0.618),the difference was not statistically significant,P> 0.05,but 6 months after operation After 1 month(P = 0.044)and 3 months,visual acuity(P = 0.029)decreased significantly,the difference was statistically significant,P <0.05;while in the control group,visual acuity at 6 months after surgery was higher than before(P = 0.030),The visual acuity improved significantly at 1 week after operation(P = 0.027),the difference was statistically significant,P <0.05,the visual acuity at 6 months after operation was compared with 1 month and 3 months after operation(P = 1.000),the difference was not statistically significant,P> 0.05.There was no statistically significant difference in visual acuity between the two groups before operation,1 week after operation,1 month after operation,and 3 months after operation,with a P value of> 0.05,while the comparison between the two groups at 6 months after operation(P = 0.021),control group The visual acuity was significantly better than that of the observation group,the difference was statistically significant,P <0.05.Thickness of GCL in each area: the observation group and the control group were compared with the preoperative one week after operation,and the thickness of each area increased after 1 week after operation,the difference was statistically significant,P = 0.000 <0.05;Compared with pre-operation,although there was a decrease compared with pre-operation,the difference was not statistically significant,P> 0.05(observation group areas: ST: P = 0.144;S: P = 1.000;SN = IN = I = IT: P = 0.1000;each area of the control group: ST: P = 0.068;S: P = 1.000;SN = IN = I = IT: P = 0.1000);but compared with one week after operation,the difference was statistically significant,P = 0.000<0.05;3 months after the operation,there was a decrease compared with the preoperative period,but the difference was not statistically significant,P> 0.05(observation group: ST: P = 0.199;S: P = 1.000;IN: P = 0.459;SN = I = IT: P =0.1000;each area of ?the control group: ST: P = 0.152;S: P = 0.477;SN = IN = I = IT: P = 0.1000);but compared with 1 week after operation,the thickness Thinning,the difference was statistically significant,P= 0.000 <0.05;the difference between the observation group at 6 months after operation and pre-operation,1 week after operation,1 month after operation,and 3 months after operation was statistically significant,P= 0.000 <0.05;the difference between the 6-month postoperative group and the preoperative and 1 week postoperative groups was statistically significant,P = 0.000 <0.05,the 6-month postoperative period was compared with the 1-month postoperative period and 3-month postoperative period,and there was no statistical difference In terms of academic significance,P> 0.05(P values are all 1.000);compared between the two groups after 6 months,the thickness of each area of the control group was significantly thicker than that of the observation group,the difference was statistically significant,P = 0.000 <0.05.Conclusion:1.The thickness of the ganglion cell layer in the observation group and the control group changed accordingly,that is,the thickness of the two groups increased at 1 week after operation compared to the preoperative area,and at 1 month after operation compared to 1 week after operation The thickness became thinner at 3 months postoperatively than at 1 week postoperatively;at 6 months postoperatively,the thickness of each area of the observation group was significantly thinner than that of the control group.2?Silicone oil can make the thickness of the ganglion layer thinner and reduce the visual function;3?OCT can objectively evaluate the recovery of visual function.