Analysis Of Related Factors Of Delayed Encephalopathy After Carbon Monoxide Poisoning

Objective: By analyzing the factors related to the onset of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP)to determine the risk factors,provide a basis for clinically reducing the incidence of DEACMP.Methods: From January 1,2017 to December 31,2017,a total of 142 patients met study criteria with ACMP who were admitted to the emergency department of the Affiliated Hospital of Hebei Engineering University were included.The clinical data at onset and treatment process of the patients were collected.they were divided into DEACMP group and non-DEACMP group according to the occurrence of delayed encephalopathy in 3 months.An Excel database was established and SPSS 22.0software was applied for analysis.Count data were expressed by adopting the number of cases,the composition ratio and so on.Measurement data were expressed by adopting mean ± standard deviation;Count data were compared by using chi-square test.The measurement data satisfied the normal distribution.For homogeneity of variance,an independent sample t-test was used.For measurement data that cannot meet the normal distribution,a non-parametric rank sum test was used.P<0.05 was statistically significant;Statistically significant items in one-way analysis were considered as independent variables.The presence or absence of delayed encephalopathy was considered as the dependent variable to perform a two-class logistic regression analysis and determine risk factors for the occurrence of DEACMP.And the degree of influence of risk factors was ranked.Results:1.In the chi-square test,there were statistics significance on smoking history,CO exposure time,lymphocyte count,PLR,NLR,creatinine,urea,myoglobin,cardiac troponin I,electrocardiogram,and hyperbaric oxygen therapy to onset time;For gender,type of labor,history of hypertension,history of diabetes,history of coronary heart disease,red blood cell count,white blood cell count,platelet count,neutrophil count,hemoglobin,creatine kinase MB,C-reactive protein,B-type natriuretic peptide precursors,skull CT/MRI and the numbers of hyperbaric oxygenation,there were no statistically significant differences.2.In the non-parametric rank sum test,the ACMP index was statistically significant and age was not statistically significant.3.The results of multivariate logistic regression analysis were: CO exposure time,severe ACMP,PLR,cardiac troponin I were independent risk factors for DEACMP and lymphocytes were protective factors.4.The degree of influence of independent risk factors on the occurrence of DEACMP was in descending order: cardiac troponin I> PLR> CO exposure time> ACMP index.Conclusion:1.Smoking history,CO exposure time,ACMP index,lymphocyte count,PLR,NLR,creatinine,urea,myoglobin,cardiac troponin,electrocardiogram,and hyperbaric oxygen treatment to onset time are the risk factors for the occurrence of DEACMP.2.CO exposure time,ACMP index,PLR,cardiac troponin I are independent risk factors for DEACMP.The degree of influence on DECAMP is cardiac troponin I>PLR>CO exposure time>ACMP index.3.Abnormal lymphocyte count is a protective factor for DEACMP.