The Relationship Between The Expression Of CD38 And LMO2 In Non-hodgkin's B-cell Lymphoma And Clinicopathology

Objective:To investigate the expression of CD38 and LMO2 in patients with non-hodgkin's B cell lymphoma and its clinicopathological relationship.Methods:This study collected specimens from 189 non-hodgkin's b-cell lymphoma patients who were admitted to the second affiliated hospital of nanchang university from January 2018 to October 2019.The expression of CD38 and LMO2 was detected by immunohistochemistry,To explore the correlation between the two and the clinicopathology(gender,age,B symptom,mass diameter,origin of disease,number of overnode accumulations,Ann Arbor stage,pathological type,LDH).Results:(1)The positive expression rate of CD38 in b-nhl was 20.63%(39/189),of which5%(3/60)were expressed as table positive in lazy B lymphoma and 27.91%(36/129)in invasive B cell lymphoma.he positive expression rate of LMO2 in b-nhl was28.04%(53/189),18.33%(11/60)in lazy B lymphoma and 32.56%(42/129)in invasive B cell lymphoma.The positive expression rate in DLBCL was 38.75%(31/80).(2)CD38 expression in B-NHLs was negatively correlated with LMO2expression(?=-0.056,p=0.008).(3)The positive rate of CD38 in the B-NHLs group was 5%(3/60),and that in the invasive B-cell lymphoma group was 27.91%(36/129).The difference was statistically significant(?~2=13.121,P=0.000).In Ann Arbor staging?-?group,positive rate was 25.78%(33/128),?-?period group,positive rate was 9.8%(6/61),differences statistically significant(?~2=6.414,P=0.011).The positive rate of the proliferation index(ki-67>30%)group was 26.72%(35/131),and that of the proliferation index(ki-67?30%)group was 6.9%(4/58).The difference was statistically significant(?~2=9.644,P=0.002).The positive rate of LMO2 in B-NHLs inactivated B lymphoma was 18.33%(11/60),and the positive rate in invasive B cell lymphoma was 32.56%(42/129),the difference was statistically significant(?~2=4.107,P=0.043).The positive rate was 45%(27/60)in the normal LDH group and 27.91%(36/129)in the abnormal group.The difference was statistically significant(?~2=5.384,P=0.01).Ann Arbor staging?-?group,the positive rate was 39.34%(24/61),?-?period group of positive rate was 22.66%(29/128),statistically significant differences(?~2=5.702,P=0.017).The positive rate of the proliferation index(ki-67?30%)group was 50%(29/58),and the positive rate of the proliferation index(ki-67>30%)group was 25.9%(34/131),and the difference was statistically significant(?~2=10.460,P=0.002).(4)The positive rate of CD38 was 40.32%(25/62)in the LDH abnormal group of DLBCL patients,and11.11%(2/18)in the normal group.The difference was statistically significant(?~2=5.324,P=0.021).In Ann Arbor staging?-?group,positive rate was 54.55%(6/11),?-?group,positive rate was 30.43%(21/69),statistically significant differences(?~2=5.324,P=0.035);The expression rate was 52.38%(11/21)in the CD10-positive group and 27.12%(16/59)in the negative group,with statistically significant differences(?~2=5.324,P=0.036).The positive rate of LMO2 in the normal LDH group of DLBCL patients was 61.11%(11/18),and that in the abnormal LDH group was 32.26%(20/62).The difference was statistically significant(?~2=4.893,P=0.027).The positive rate was 66.67(14/21)in the CD10 positive group and28.81%(17/59)in the CD10 negative group,and the difference was statistically significant(?~2=9.350,P=0.02).The positive rate in the Bcl-6 group was 31.58%(18/57),and the positive rate in the Bcl-6 negative group was 56.52%(13/23),and the difference was statistically significant(?~2=4.296,P=0.038).Conclusion:The combined detection of LMO2 and CD38 can assist in the diagnosis of germinal center-derived lymphoma and the differential diagnosis among related subtypes,and provide a certain reference for the individualized treatment of patients.