Analysis Of The Influence Of Group B Streptococcus Infection On The Outcomes Of Maternal And Infant During Perinatal Period

Purpose:To investigate the colonization rate of GBS and the risk factors of infection in pregnant women,and to explore the effects of GBS infection on perinatal outcome.Methods:A total of 1469 pregnant women who met the inclusion criteria and exclusion criteria for regular prenatal examination in the first affiliated Hospital of Nanchang University from May 2018 to June 2019 were collected secretion of the place under vaginal 1/3 and rectum,with the informed consent of pregnant women.GBS was detected by PCR technology,while take leucorrhea to implement Candida albicans and Gardnerella albicans analysis.According to the results of GBS detection,the patients were divided into two groups: GBS positive group and GBS negative group.The pregnancy outcomes of the two groups were observed,and used SPSS24.0statistical software to analyze the risk factors of GBS infection.Results:1.The colonization rate of GBS was 4.08%,in which the positive rate of GBS in pregnant women aged more than 35 years old was 6.35%,and the positive rate of GBS in pregnant women under 35 years old was 3.87%.GBS positive rate of women in primiparity was 3.90%,GBS positive rate of multipara was 4.23%.The positive rate of GBS in pregnant women with more than 3 miscarriages was 0%,and the positive rate of GBS in pregnant women with less than 3 miscarriages was 4.27%.The positive rate of GBS in diabetic pregnant women(including gestational diabetes mellitus and diabetes mellitus with pregnancy)was 13.16%,and that of GBS in non-diabetic pregnant women was 3.59%.There was no significant difference in maternal age,parity and miscarriage times between the two groups(P>0.05),but there was significant difference in diabetes mellitus between the two groups(P<0.01).2.The positive rate of Candida albicans was 13.21%.The positive rate of Gardnerella was 30.36%.In the GBS positive group,the positive rate of Candida albicans and Gardnerella was 16.67% and 28.33% respectively;and the GBS negativegroup,the positive rates of Gardnerella albicans and Gardnerella was 13.06% and30.45% respectively.There was no statistical difference in the infection rate of Candida albicans and Gardnerella between GBS positive group and GBS negative group(P>0.05).3.In the GBS positive group,the incidences of premature rupture of membranes,intrapartum fever,amniotic fluid contamination,preterm delivery,cesarean section,postpartum fever and postpartum hemorrhage was 33.33%?0%?16.67%?18.33%?56.67%?11.67%?1.67% respectively.In GBS negative group,the incidences of premature rupture of membranes,intrapartum fever,amniotic fluid contamination,preterm delivery,cesarean section,postpartum fever and postpartum hemorrhage were 24.77%?2.91%?20.87%?7.60%?49.54%?14.55%?1.06% respectively.There was no statistical difference in the incidence of premature rupture of membranes,intrapartum fever,amniotic fluid contamination,cesarean section,postpartum fever and postpartum hemorrhage between the two groups(P>0.05),but there was significant statistical difference in the incidence of preterm delivery between the two groups(P<0.01).4.In the GBS positive group,the incidence of fetal distress,neonatal asphyxia,neonatal pneumonia,neonatal septicemia,pathological jaundice and conversion to NICU was 6.67%?8.33%?5.00%?5.00%?28.33%?30.00% respectively.In the GBS negative group,the incidence of fetal distress,neonatal asphyxia,neonatal pneumonia,neonatal septicemia,pathological jaundice and conversion to NICU was 7.38% ?2.91%?0.92%?0.14%?18.10%?26.26% respectively.There was no statistical difference in the incidence of fetal distress and conversion to NICU between the two groups(P>0.05),but there was statistical difference in the incidence of neonatal asphyxia,neonatal pneumonia,neonatal septicemia and pathological jaundice between the two groups(P<0.05).There was a significant statistical difference in neonatal septicemia between the two groups(P <0.01).Conclusions:1.The total colonization rate of GBS in pregnant women was 4.08%.There was no significant correlation between maternal age,parity and miscarriage times and GBS infection;diabetes was an independent risk factor for GBS infection.2.There is no significant correlation between Candida albicans and Gardnerella infection and GBS infection in pregnant women.3.GBS infection increases the incidence of preterm delivery,but has no significant correlation with premature rupture of membranes,intrapartum fever,amniotic fluid contamination,cesarean section,postpartum fever,postpartum hemorrhage.4.GBS infection increases the incidence of neonatal asphyxia,neonatal pneumonia,neonatal septicemia and pathological jaundice,but has no significant correlation with fetal distress and conversion to NICU.