Clinical Value Analysis Of CA125 Combined MHR In Diagnosis Of Heart Failure

Objective:This paper mainly studies the diagnostic value of serum tumor marker carbohydrate antigen 125(CA125)combined with monocyte/high density lipoprotein cholesterol ratio(MHR)in patients with heart failure(HF)with different left ventricle ejection fraction(LVEF).At the same time,we can find out the difference between CA125 and MHR among the heart failure with preserved ejection fraction(HFpEF)patients with different diastolic dysfunction through this study.Methods:A total of 360 inpatients from January 2017 to June 2019 in the first affiliated Hospital of Nanchang University were divided into normal control group(n=102)and heart failure group(n=258).According to the index of ejection fraction of cardiac color Doppler ultrasound,heart failure group was divided into two groups:heart failure with preserved ejection fraction group(n=126)and non-heart failure with preserved ejection fraction group(n=132).The difference of biochemical indexes and echocardiographic indexes were analyzed.?According to the related indexes of echocardiography,the patients with heart failure with preserved ejection fraction group were divided into three groups:mild diastolic dysfunction(n=64),moderate diastolic dysfunction(n=110)and severe diastolic dysfunction(n=84).The relationship between diastolic function grade and CA125 and MHR was analyzed and compared.Results:A total of 102 patients in normal control group,126 patients in heart failure with preserved ejection fraction group and 132 patients in non-heart failure with preserved ejection fraction group were analyzed.There was no significant difference in N-terminal pro-B type natriuretic peptide(NTproBNP),CA125,left atrial diameter,right ventricular diameter and left ventricular end-diastolic diameter(LVEDD)(P<0.05)among the three groups except MHR(P>0.05).Age,CA125,smoking and drinking were included in the model by logistics regression analysis.It was found that the risk of heart failure with preserved ejection fraction group with high CA125(CA125>22.35)non-heart failure with preserved ejection fraction group was 8.62 times(P<0.001)and 13.16 times(P<0.001)higher than that in normal group,respectively.The risk of heart failure with preserved ejection fraction was 1.51 times higher than that in non-heart failure with preserved ejection fraction group,and there was no significant difference between the two groups(P>0.05).There was no significant difference in the risk of heart failure with preserved ejection fraction and non-heart failure with preserved ejection fraction between smoking and drinking(P?0.05).The left ventricular diastolic function was divided into four groups by modified ASE/EAE method.In the normal group,mild diastolic dysfunction group,moderate diastolic dysfunction group and severe diastolic dysfunction group,there were significant differences in the anterior and posterior diameter of the left atrium,the diameter of the right ventricle and the end of the left ventricle(P<0.05),but there was no significant difference in the diameter of the right ventricle and MHR(P>0.05).The correlation coefficients between the degree of diastolic dysfunction and the left atrial diameter,right ventricular diameter,left ventricular end diastolic diameter,CA125,NTproBNP,were respectively 0.102(P<0.05)?0.187(P<0.05)?0.216(P<0.05)?0.102(P<0.05)?0.104(P<0.05).The correlation coefficients was 0.211(P>0.05)between the degree of diastolic dysfunction and MHR.Conclusions:CA125 has good specificity and sensitivity in the diagnosis of heart failure.CA125 is an independent risk factor for heart failure.MHR has poor specificity and sensitivity in diagnosing heart failure.and the correlation between the degree of diastolic dysfunction and CA125 was low.