Can Polyglycolic Acid Reduce Postoperative Recurrence Of Spontaneous Pneumothorax

Objectives:Systematic evaluation of the therapeutic effect of polyglycolic acid mesh on bullous pneumonectomy under thoracoscopy.Methods:A comprehensive literature search was performed using ScienceDirect,EMBASE,Ovid MEDLINE,PubMed,The Cochrane Library,Scopus,Wang fang,Zhi wang,Vip,and Google Scholar.Clinical trials that compared PGA versus non-PGA for bullectomy were selected.The clinical endpoints included postoperative recurrence,average postoperative air leakage,prolonged air leaks,drainage tube removal time,and postoperative hospital stay.The Review Manager 5.3 software was used for meta analysis.Results:A total of eight articles(1034 patients)were included.Compared to the non-PGA approach,the PGA approach was associated with lower rates of postoperative recurrence(95% confidence interval [CI]: 0.16 to 0.39,p < 0.00001),)and of prolonged air leaks(95% CI: 0.29 to 0.72,p = 0.0007);a shorter time of drainage tube removal(95% CI:-1.36 to-0.13,p = 0.02);The time of average postoperative air leakage,postoperative hospital stay and operative time did not show a significant difference between the two groups.Conclusions:These results suggest that the use of PGA patch might can prevent the postoperative recurrence of spontaneous pneumothorax and decrease the rates of prolonged air leaks.The postoperative hospital stay and operation time were not increased.More large-scale,high-quality randomized controlled trials are required to confirm our finding.