Influences Of Severe Obstructive Sleep Apnea-hypopnea Syndrome And Abdominal Obesity On Cognitive Function

Objective:To explore the influences of severe OSAHS and abdominal obesity on adult cognitive function and blood levels of A?40,A?42,and tau protein,and further analyze whether there is an interaction of severe OSAHS and abdominal obesity on cognitive function.Method:1.First of all,we collected the basic characteristics and medical history of all the subjects,and used the Epworth sleep scale to evaluate the subjective sleepiness.Then the MoCA scale was used to evaluate the overall cognitive function and sub-functions of 196 subjects undergoing polysomnography in the First Affiliated Hospital of Nanchang University,and the.The SDMT and TMT-A scales were used to evaluate the attention and information processing speed of 161 subjects.Andthe polysomnography indicators were collected.Finally,radioimmunoassay was used to detect the blood protein levels of A?40,A?42 and tau of 45 subjects.2.According to AHI,the subjects were divided into two groups: severe OSAHS and no to moderate OSAHS.The differences in evaluation indicators of the cognitive scale andin the three protein levels were compared between the two groups with or without adjusting for confounding factors.Then the subjects were divided into non-abdominal obesity and abdominal obesity groups,and The differences in evaluation indicators of the cognitive scale andin the three protein levels between the two groups were also compared.Llinear regression models were used to clarify the independent influential factors of various cognitive functions and blood protein levels,and to determine whether severe OSAHS and abdominal obesity were independently related to various cognitive abilities and blood protein levels.3.The subjects were divided into four groups,includingno to moderate OSAHS with non-abdominal obesity group,no to moderate OSAHS with abdominal obesity group,and severe OSAHS with non-abdominal obesity group.ANOVA was used to compare the differences in cognitive function among the four groups.Two-wayanalysis of variance was used to detect and analyze the main effects and interactions of severe OSAHS and abdominal obesity on various cognitive functions after adjusting for confounding factors.Result:1.The delayed recall score and total score of MoCA scale of subjects in severe OSAHS group were significantly lower than those in no-to-moderate OSAHS group(P <0.05);After adjusting for gender,age,years of education,ESS score,abdominal obesity,smoking and drinking,the delayed recall score and total score of the MoCA scale and the correct number of SDMT in the severe OSAHS group were significantly lower than those in the no to moderate OSAHS group(P <0.05).After adjusting for gender,age,years of education,ESS score,abdominal obesity,smoking and drinking,the A?40 protein level in blood in the severe OSAHS group was significantly lower than that in the no-to-moderate OSAHS group(P <0.05).The visual/spatial and executive function score,language score and total score of MoCA scale of subjects in abdominal obesity group were significantly lower than those in non-abdominal obesity group(P <0.05).After adjusting for gender,age,years of education,ESS score,severe OSAHS,smoking and drinking,the visual/spatial and executive function and language scores of MoCA scale in abdominal obesity group were significantly lower than those in non-abdominal obesity group(P <0.05).A?40,A?42,tau protein in blood in abdominal obesity group were significantly higher than in non-abdominal obesity group with or without adjusting for gender,age,years of education,ESS score,severe OSAHS,smoking and drinking(P <0.05).2.Linear regression analysis showed that severe OSAHS was independently negatively associated with delayed recall score and total score of Moca scale and SDMT correct number(P <0.05),Abdominal obesity was independently negatively associated with visual/spatial executive and language score(P <0.05).Severe OSAHS was independently negatively associated with A?40 protein levels(P <0.05),and abdominal obesity was independently positively associated with A?40,A?42,and tau protein levels in blood(P <0.05).3.After adjusting for gender,age,years of education,ESS score,smoking history and drinking history,there was a main influence of severe OSAHS on thedelayed recall and total score in MoCA,and the correct number of SDMT(P <0.05).There was a main influence of abdominal obesity on the visual/spatial executive function and language score of MoCA scale.An interactive effect of severe OSAHS and abdominal obesity on the language score of Moca scale was seen(P <0.05).Conclusion:1.Compared with those with no to moderate OSAHS,those with severe OSAHS performed worse in overall cognition,delayed recall,executive function and processing speed,and had lower A?40 protein levels in blood.Compared with those with non-abdominal obesity,those with abdominal obesity had worse performance in visual/spatial and executive function and language ability,and had higher levels of A?40,A?42 and tau protein in blood.Severe OSAHS was an independent influential factor of overall cognition,delayed recall,attention and processing speed,and A?40protein level in blood.Abdominal obesity was an independent influential factor of visual/spatial and executivefunction,language ability,and A?40,A?42,and tau protein levels in blood.2.There was an interaction effect of severe OSAHS and abdominal obesity on language ability.