Relationship Between Shaking Legs Habits And Thrombotic Diseases

Background:In today's society,due to the aging population and changes in people's lifestyles and habits,thrombotic diseases have become a major global health problem.At present,the top three lethal cardiovascular diseases in the world are myocardial infarction,stroke and venous thromboembolism?VTE?,and thrombosis is the common mechanism of their pathogenesis,because of its high concealment,it is also known as no line killer.In clinic,thrombotic disease is caused by two pathological processes:thrombosis and thromboembolism.After thrombosis,it will block the blood flow of the corresponding organs or tissues,or fall off as a embolus,blocking the blood flow of distant organs or tissues.This can lead to ischemia or even necrosis of organs or tissues^[1].According to the survey data of the World Health Organization,as many as 16 million people die from cardio-cerebrovascular disease each year,and deaths caused by thrombotic diseases in China account for 51%of the total deaths in the world,and the central cerebral vascular embolism accounts for very high proportion^[2].Thrombotic diseases mainly include two aspects:?1?venous thrombotic diseases:namely venous thromboembolism?VTE?,including pulmonary thromboembolism?PTE?and deep vein thrombosis?DVT?;?2?arterial thrombotic diseases:Including acute coronary syndrome?ACS?,arterial ischemic attack,stroke,etc^[3].On the other hand,as the risk factors of thrombotic diseases?such as smoking,drinking,obesity,sedentary,etc.?continue to increase in the population,leading to thrombotic diseases become one of the major diseases that threaten human health and life in today's society^[2].Therefore,actively preventing and treating thrombotic diseases and minimizing their prevalence has become an important goal in the prevention and treatment of thrombotic diseases.In daily life,shaking legs is often seen,but there is no clear definition and related further research.As the Chinese saying goes:"males shake poorly,females shake poorly",leg shaking is also considered a bad habit,and the impact of leg shaking on people's health also lacks relevant evidence.On the other hand,shaking the legs can help improve blood flow to the lower limbs,promote blood circulation,especially for those who have sedentary behaviors,and exercise can reduce the occurrence of thrombotic diseases,which is supported by reliable scientific evidence^[4].Objective:To study the relationship between shaking legs habits and thrombotic disease.Method:Take 1020 individuals collected from February 2018 to January 2019 through a questionnaire.The questionnaire content includes:gender,age,education,shaking legs,smoking,drinking,activity,hypertension,hyperlipidemia,diabetes,atrium fibrillation?AF?,heart failure?HF?or cardiomyopathy?CM?,chronic kidney disease?CKD?or nephrotic syndrome?NS?,severe liver disease,chronic lung disease or pulmonary hypertension?PH?,sleep apnea syndrome?SAS?,cancerous disease,and psychological stress.The questionnaires were introduced to the respondents in detail before they were filled out.For those who are more ill,they can be written by their families,for those with lower education,they can be filled out by the investigators according to the patient's situation and perform univariate and multivariate Logistic regression analysis to analyze correlation between shaking legs and thrombotic diseases.Result:1?Of the 368 individuals with thrombotic diseases,283 had no legs shaking habit?76.9%?;among 652 non-thrombogenic diseases,355 had no legs shaking habit?54.4%?,individuals with thrombotic diseases and non-thrombotic diseases differences in shaking legs rates among individuals were statistically significant??²=51.10,P<0.05?;gender differences were not statistically significant?P>0.05?;2?thrombotic disease age,proportion of smoking,proportion of drinking,proportion of non-shaking legs,sedentary,hypertension,hyperlipidemia,diabetes,atrial fibrillation,heart failure or cardiomyopathy,chronic kidney disease or nephrotic syndrome,severe liver disease,chronic lung disease the prevalence rates of pulmonary hypertension,sleep apnea syndrome,cancerous diseases and psychosocial stress were higher than those of non-thrombotic disease group,the difference was statistically significant?P<0.05?.3?Multivariate Logistic regression analysis showed that smoking,drinking,sedentary,atrial fibrillation,heart failure or cardiomyopathy,chronic kidney disease or nephrotic syndrome,severe liver disease,chronic lung disease or pulmonary hypertension,sleep apnea syndrome,cancerous diseases and psychosocial stress are all thrombotic diseases independent risk factors;after adjustment for potential confounders,such as smoking,drinking,activity and so on,those who do not have a shaking legs habit are more likely to develop thrombotic diseases than those who have a shaking legs habit?OR=1.85;95%CI:1.044,3.273;P=0.035<0.05?.Conclusion:1?The shaking legs habits is related to thrombotic diseases;2?Multivariate Logistic analysis shows that the shaking legs habits may reduce the incidence of thrombotic diseases.