Fractional Anisotropy In DTI And DKI For Cerebral Changes Of Patients With Depression

Objective:To evaluate cerebral lesions in depression patients using fractional anisotropy(FA)values of diffusion tensor imaging(DTI)and kurtosis fractional anisotropy(KFA)values of diffusion kurtosis imaging(DKI),to provide meaningful information for the clinical diagnosis and treatment of depression from the perspective of neuroimaging.Methods:1.From October 2018 to October 2019,40 inpatients and outpatients in the First Affiliated Hospital of Shihezi University were collected,and 20 patients with depression were selected as the case group,according to the DSM-V,including 15 females and 5 males,whose ages ranged from 15 to 71 years,the average age was(44.7±14.9)years.The control group consisted of 20 healthy volunteers,including 15 females and 5 males,whose ages ranged from 15 to 71 years,the average age was(45.9±13.3)years.2.All participants were assessed with the Hamilton depression scale(HAMD).Both groups were examined by conventional MRI to exclude organic lesions,and then DTI and DKI scans were performed.3.Import the original data scanned by all subjects into the GE ADW4.6 workstation,and use Functool for image post-processing,the FA values based on DTI,FA and KFA values based on DKI of genu of corpus callosum and pressing part,bilateral occipital lobe,bilateral frontal lobe,bilateral temporal lobe were compared between case group and control group.4.SPSS20.0 was used for statistical an alysis of all the data,and t he measurement data were expressed as(x ±s)with normal distribut ion.Two independent samples T test was used for comparison between the two groups,and the level of bilateral test was α=0.05.Results:1.There was no statistically significant difference in age and sex between depression group and control group(P>0.05).The average score of HAMD was(4.60±1.63)in the control group,and(28.65±7.48)in the case group,and the difference was statistically significant(P<0.05).2.Comparison of FA values of DTI in different regions: There was no statistically significant difference in the FA values of genu of corpus callosum and pressor region,bilateral occipital lobe,bilateral superior frontal gyrus,middle frontal gyrus,inferior frontal gyrus in the depression group and the control group(P>0.05).Compared with the control group,the FA value of bilateral temporal lobes i n the depression group was lower,and the difference was statistically significant(P<0.05).3.Comparison of FA values of DKI in different regions:There was no statistically significant difference in the FA values of genu of corpus callosum and pressor region,bilateral occipital lobe,bilateral superior frontal gyrus,middle frontal gyrus,inferior frontal gyrus in the depression group and the control group(P>0.05).Compared with the control group,the FA value of bilateral temporal lobes in the depression group was lower,and the difference was statistically significant(P<0.05).4.Comparison of KFA values of DKI in different regions: There was no significant difference in KFA values of left superior frontal gyrus,right middle frontal gyrus,bilateral inferior frontal gyrus,occipital lobe,corpus callosum knee and pressor part between case group and control group(P>0.05).Compared with the control group,the KFA values of bilateral temporal lobe,left middle frontal gyrus and right superior frontal gyrus in the case group were lower,and the differences were statistically significant(P<0.05).Conclusion:1.There were FA and KFA decreased in depression patients,which suggested that there might be some changes of brain microstructure in depression patients.2.The decrease of KFA in depressed patients was more than that in FA,suggesting that DKI is more sensitive to detect the potential brain changes of depression.