Functional Magnetic Resonance Imaging To Evaluate Renal Function And Grogression In Lupus Nephritis

Objective:We expected fMRI could play a noninvasive role in the diagnosis of lupus nephritis.In recent years,with the development of functional MR,studies on the prediction of renal function have been gradually carried out.However,there is a lack of studies on the combination of functional MR with histopathology and the evaluation of long-term renal function changes in patients with LN.Therefore,this study intends to explore the role of functional magnetic resonance imaging combined with histopathological features in predicting the extent of LN tissue damage,assessment the change slope of renal creatinine in patients with LN by observing the correlation between multi-mode functional magnetic resonance imaging and renal tissue activity score.Methods:32 patients with lupus were enrolled.The sequences included intravoxel incoherent motion diffusion imaging(IVIM-DWI),diffusion tensor imaging(DTI),and blood-oxygen-level dependent imaging(BOLD).Magnetic resonance imaging(MRE).The sequence parameters of renal cortical functional imaging were analyzed and recorded.Baseline clinicopathological data and follow-up data for LN patients were analyzed.Results:We found that The standard-ADC(14.96±1.21,10-6mm2/sec vs 18.15±1.43,10-6mm2/sec,p<0.05)and FA(0.141±0.02,um2/ms 0.187±0.03,um2/ms,p<0.05)descended in the subgroup(CI≥3)of lupus nephritis.In follow-up period,FA(0.164±0.031 vs 0.195±0.065,p<0.001)is much lower in the patients with renal function deterioration,and correlated with the descending slope of serum creatine.The DTI-FA had a predictive value for the change of serum(AUC 61.5%,p<0.05).We did not found any differences between LN with CKD in BOLD and MRE.Conclusion:DTI-FA and IVIM-ADC is promising in prediction of renal function.More effort should be paid to monitor prognosis in the future.