Clinical Study On The Eradication Of Helicobacter Pylori Infection With Pingwei Capsule

Objective: To observe the eradication rate of Helicobacter pylori(Hp)infection and the improvement of clinical symptoms.To compare the therapeutic effect of Pingwei Capsule group,bismuth pectin group and Bifidobacterium group in the treatment of Hp infection,and to explore the correlation between the three schemes in the eradication rate of Hp and the degree of clinical symptom relief,so as to provide some scientific basis for the eradication of Hp in traditional Chinese medicine.Methods: From January 2019 to December 2019,180 patients with Hp infection with damp heat syndrome of spleen and stomach were randomly divided into Pingwei Capsule group,bismuth pectin group and Bifidobacterium group.Bismuth in pectin group was treated with bismuth tetralogy(Rabeprazole 10 mg bid,Amoxicillin 1g bid,Clarithromycin 0.5g bid,colloidal pectin bismuth 150 mg tid),Pingwei Capsule group(Rabeprazole 10 mg bid,Amoxicillin 1g bid,Clarithromycin 0.5g bid,Pingwei Capsule 2g tid),Bifidobacterium group(Rabeprazole 10 mg bid,Amoxicillin 1g bid,Clarithromycin 0.5g bid,Bifidobacterium triple viable tablet 1.5g bid)were taken for 14 days.The general data of patients were collected before treatment,and breath test was rechecked one month after the medication was stopped to clarify the difference of Hp eradication among the three groups,and the clinical symptom score was evaluated before and after the medication to compare the curative effect before and after treatment,and adverse reactions during the experiment were collected.Results: Of the 180 patients included,11 dropped out of the study and were treated as dropped cases.Therefore,169 cases were finally included in the study,including 58 cases in Pingwei Capsule group,55 cases in pectin bismuth group and 56 cases in Bifidobacterium group.The specific results are as follows:1.Baseline data: there was no significant difference in age,gender and DOB value of expiratory test among the three groups before treatment,so there was comparability among the three groups.2.Comparison of Hp eradication rate: 52 of 58 patients in Pingwei Capsule group were eradicated,the eradication rate was 89.7%,47 of 55 patients in pectin bismuth group,the eradication rate was 85.5%,41 of 56 patients in Bifidobacterium group,the eradication ratewas 73.2%.The difference of Hp eradication rate among the three groups was statistically significant(P = 0.029 < 0.05).Chi square test showed that there was no significant difference between Pingwei Capsule group and pectin bismuth group,and there was significant difference between Bifidobacterium group and the other two groups.3.Clinical symptom score comparison: the clinical symptom scores of the three groups were significantly different before and after treatment(P < 0.05),indicating that the three groups of drugs can improve the clinical symptoms.The difference of clinical symptom scores between Pingwei Capsule group and the other two groups was statistically significant(P < 0.05);the difference between pectin bismuth group and Bifidobacterium group was not statistically significant(P > 0.05).There was significant difference in the distribution of total effective rate among the three groups(P < 0.05).The effect of Pingwei Capsule group was higher than that of the other two groups.There was no significant difference between bismuth pectin group and Bifidobacterium group(P > 0.05).Conclusion:1.The eradication rate of Hp in Pingwei Capsule group was the same as that in bismuth quadruple therapy.2.Pingwei Capsule group can obviously improve the clinical symptoms of Helicobacter pylori infection(Syndrome of liver depression and spleen deficiency with damp heat).