Results Of Low-dose Computer Tomography For Lung Cancer Screening Among Community Residents From Changchun

Objectives:To analyze the positive pulmonary nodules and lung cancer detected by low-dose computer tomography and their related epidemiological characteristics to provide a basis for the implementation of lung cancer screening in China.Methods:From October 2018 to December 2018,969 eligible subjects were recruited through voluntary registration in 5 communities in Changchun City.Questionnaire survey and LDCT scans were performed,and patients with positive nodules were followed up for 1 year.Analyze the epidemiological characteristics of the tested population,and describe the detection of nodules,lung cancer,and other lung diseases.And we analyze the correlation between lung cancer and positive nodules and the relevant epidemiological characteristics.Results:1.Investigation of the epidemiological characteristics of the subjects:Among the 969 subjects,442 were males and 527 were females,ranging in age from 40 to 75 years old.There were 430 subjects with a history of smoking(341 males,89 females),390 subjects with a history of passive smoking(317 females,73 males),and 484 subjects with exposure to cooking fume(69 males,415 females).There were statistically significant differences in the number of smokers,passive smokers and cooking fume exposure between genders(P<0.05).83 subjects with occupational exposure to dust(8.6%,83/969).There were 112 subjects of lung disease(11.6%,112/969),158 subjects of family history of lung cancer(16.3%,158/969),55 subject of pulmonary tuberculosis(5.6%,55/969),45 subjects of diabetes(4.6%,45/969),and 29 subjects of home coal burning(3.0%,29/969).2.Pulmonary nodule detection: A total of 497 subjects(51.3%,497/969)with pulmonary nodules were detected in this screening,of which 120 were positive(24.1%,120/497).The proportion of male patients with positive nodules was higher than that of female patients,and the difference was statistically significant(P=0.0095).The smoking rate,cooking oil fume exposure rate,total smoking duration,daily smoking amount,smoking index,age,occupational exposure to coal dust and dust exposure rate of the positive nodule group were statistically significant compared with the non-positive nodule group(P<0.05).3.Lung cancer detection: Seven patients of lung cancer were detected,and the detection rate of lung cancer was 0.72%(7/969).The histopathological types were all lung adenocarcinomas.Based on the the eighth edition of the TNM stage,six lung cancer were stage I and one was stage IV at the time of diagnosis..4.Other pulmonary diseases detection: One patient of false positive result confirmed by invasive operation in this screening.Emphysema was detected in 215 cases(22.2%,215/969),small airway lesions disease was screened in 77 cases(8.0%),and interstitial lung disease(ILD)was screened in 36 cases(3.7%,36/969).Conclusions:1.497 patients of nodules were detected in this LDCT screening,and the detection rate of nodules was 51.3%(497/969),among which 120 subjects were positive(24.1%,120/497),and 7 cases of lung cancer were confirmed by pathology within one year(0.72%,7/969).2.Lung cancer screening through LDCT can detect early lung cancer,and patients can get early treatment.