The Effects Of Oxycodone On The Quality Of Anesthesia Recovery In Patients Undergoing UPPP

Objective:To explore the effect of fentanyl and oxycodone on the anesthesia recovery period of patients undergoing uvulopalatopharyngoplasty?UPPP?,and to compare the advantages and disadvantages of them in postoperative recovery.Method:From January 2019 to December 2019,60 patients underwent UPPP operation under general anesthesia in The second hospital of Jilin University were randomly divided into two groups:the experimental group?group O?and the control group?Group F?.Both groups chose total intravenous anesthesia to induce and maintain with the same drugs.Induction selection:midazolam,etomidate,cisatracurium,fentanyl.Propofol and remifentanil for maintenance.Twenty minutes before the end of the operation,fentanyl 0.0015mg/kg was added to group F,and oxycodone 0.1mg/kg was added to group O.Discontinue medication at the end of the operation.Record the following data:1.General information of patients:age,height,weight,etc.2.The mean arterial pressure,heart rate and SpO₂ were measured after 5 minutes in the operating room?T0?,immediately after extubation of tracheal tube?T1?,3 minuts after extubation?T2?,10 minutes after extubation?T3?.3.The time of eye opening,extubation and recovery of orientation force after operation.4.Calculate the difference of blood pressure fluctuation between the two groups before and after operation|T3-T0|.5.Adverse events were recorded:restlessness,tachycardia,bradycardia,respiratory depression,tracheal catheter intolerance,etc.6.Pain score.Result:1.The general information of the control group and the experimental group:gender,height,weight and other differences were not statistically significant?P>0.05?.2.There was no statistical significance between the mean arterial pressure?MAP?of the two groups at all the time points involved in this experiment;there was no statistical significance between the heart rate of the two groups at T0,T2,T3 but T1;blood pressure fluctuation|T3-T0|has no statistical significance between the two groups?P=0.735?.3.The difference of SpO₂ between the two groups at T0 and T1 time points was not statistically significant?P>0.05?,but at T2 and T3 time points was statistically significant?P<0.05?.4.The statistical data showed that the difference of eye opening time between the two groups was statistically significant?P=0.036?,the difference between the extubation time was not statistically significant?P=0.143?,the difference between the advers time was statistically significant?P=0.016?.5.In the experimental group,there were 0 cases of pruritus,4 cases of respiratory depression,0 case of bradycardia,1 case of tachycardia,5cases of restlessness,1 case of tracheal catheter intolerance;in the control group,there were 1 case of pruritus,8 cases of respiratory depression,2cases of bradycardia,0 case of tachycardia,0 case of high or low blood pressure,11 cases of restlessness;7 cases of tracheal catheter intolerance.?² test was carried out between the two groups,only the difference of tracheal catheter intolerance was statistically significant,other differences were not statistically significant.6.There was no significant difference in pain score between the two groups?P=0.714?.Conclusion:Compared the recovery of patients undergoing uvulopalatop-haryngoplasty?UPPP?under general anesthesia with fentanyl and oxycodone,we conclude that:1.Oxycodone was used in the anesthesia of UPPP operation in patients with obstructive sleep apnea hypoventilation syndrome?OSAHS?.During the recovery period,the respiratory depression of patients is less than that of fentanyl.2.Oxycodone was used in the anesthesia of UPPP opperation in patients with obstructive sleep apnea hypoventilation syndrome?OSAHS?to shorten the time of consciousness recovery and increase the tolerance of tracheal catheter after consciousness recovery.