Effects Of Different Dosages Of Oxycodone Hydrochloride On Induction Of General Anesthesia In Endoscopic Sinus Surgery In Patients With Hypertension

Objective:To observe the effects of different dosages of oxycodone hydrochloride on hypertensive patients during induction of general anesthesia in nasal endoscopic surgery.Methods:A total of 90 hypertensive patients in class?during general anesthesia in nasal endoscopic surgery were selected and randomly divided into three groups,each group have 30 cases,O₁ group of oxycodone 0.15 mg/kg,the O₂group of oxycodone 0.20 mg/kg,O₃ group of oxycodone 0.25 mg/kg,the rest of the induction of drugs and drug delivery order:midazolam 0.03 mg/kg,etomidate 0.30 mg/kg,shun benzene sulfonic acid atracurium 0.20 mg/kg.To record the mean arterial pressure?MAP??heart rate?HR?and blood glucose?Glu?before induction?T₀?,immediately before intubation?give oxycodone after 5 min??T₁?,immediately after intubation?T₂?,1 min after intubation?T₃?,5 min after intubation?T₄?,recording anesthesia time,waking up time,extubation time,dosage of propofol and remifentanil,the incidence of adverse situation,the application of atropine,esmolol and ephedrine.Differences between the two groups were compared by SNK-q.The different time points were analyzed by repetitive measure analysis of variance.Differences between enumeration data were compared by Fisher.P<0.05 for the difference was statistically significant.Results:1.There were no significant differences in general data and anesthesia time,recovery time and extubation time between the three groups?P>0.05?.2.Compared with T₀,the MAP,HR and Glu of the three groups from T₁to T₄ were significantly lower?P<0.05?;the MAP,HR and Glu at the T₂ time in the group O₁ were significantly higher than those at the T₁?P<0.05?.3.The fluctuations of MAP,HR and Glu in group O₂ were significantly less than those in O₁ and O₃ groups?P<0.05?.4.The doses of propofol and remifentanil in group O₂ and O₃ were significantly lower than those in group O₁?P<0.05?.There was no significant difference in the dose of propofol between O₂ and O₃?P>0.05?,but the difference in the amount of remifentanil was statistically significant?P<0.05?.5.There were no significant differences in the incidence of intervention and adverse reactions between the three groups?P>0.05?.Conclusion:Oxidative infusion of 0.2 mg/kg oxycodone hydrochloride for general anesthesia can improve the hemodynamic stability of patients with hypertension,reduce the dose of anesthesia,and have fewer adverse reactions.It is a safe and suitable dose.