Risk Factors And Early Diagnosis Of Sepsis Caused By Liver Abscess

Objective:Despite advances in diagnostic techniques and treatment strategies,pyogenic liver abscess(PLA)remains a life-threatening disease.The aim of this study was to analyze the clinical and microbial characteristics of PLA patients and to determine the risk factors and biomarkers for early diagnosis of sepsis caused by PLA.Methods:The demographic and clinical data of 198 patients with liver abscess admitted to Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medical from January 2013 to June 2017 were analyzed retrospectively.Results:The mortality of sepsis caused by liver abscess was 20.8%.White blood cell count,neutrophile percentage,and PCT at admission predicted the progression of PLA patients to sepsis.AUC was 0.76(95%CI 0.623-0.898),0.818(95%CI 0.691-0.945)and 0.869(95%CI 0.765-0.974)respectively.Patients with diabetes mellitus tend to develop sepsis after liver abscess.Length of stay(LOS)of patients with sepsis was significantly prolonged(19.6±12.5 VS 16.0±9.3,P=0.033).Conclusions:Diabetes mellitus is an independent risk factor for the progression of liver abscess to sepsis.The increase of white blood cell count(?12.55×10~9/L),neutrophile ratio(?84.8%),and PCT(?6.96ng/ml)in patients with liver abscess suggests that the patient progress to sepsis,and the LOS and mortality of patients with sepsis is significantly prolonged.