| Objective: To investigate the phenomenon and factors of aspirin resistance(AR)and aspirin sensitivity(AS)in patients with high altitude coronary heart disease.Methods: The research subjects of this subject come from the long-term life(> 10 years)of patients with coronary heart disease who were hospitalized in Qinghai Provincial People's Hospital from December 2018 to November 2019,and oral aspirin enteric-coated tablets 100 mg / d,Serve for at least 7 days,including 65 cases of the Han nationality and 25 cases of the Tibetan nationality.3ml of morning urine was collected.The value of urine 11-dehydrothromboxane B2 was measured by enzymelinked immunoassay.After the first blood test indicators,such as blood routine,liver,kidney function,blood lipids,glycated hemoglobin,C-reactive protein.Results: The detection rate of AR in 90 patients with coronary heart disease was 27.8%,the detection rate of AR in Han patients was 26.2%(17/65),and the detection rate of AR in Tibetan patients was 32.0%(8/25).There was no statistically significant difference in the detection rate of AR between the Han and Tibetans(p = 0.79).According to the comparison between AR and AS,body mass index,C-reactive protein,average erythrocyte volume,average erythrocyte hemoglobin content,total bilirubin,direct bilirubin,and indirect bilirubin have significant statistical differences(P <0.05)The binary logistic regression analysis of body mass index,C-reactive protein,average red blood cell volume,and average red blood cell hemoglobin content showed that BMI(P <0.05)and CRP(P <0.05)had an effect on AR.The TBIL,DBIL and IBIL in the AR group were significantly higher than those in the AS group(P <0.05).Conclusions: 1.AR phenomenon exists in patients with coronary heart disease taking aspirin in the plateau area,and there is no difference in the detection rate of AR between Tibetans and Hans.2.BMI and CRP are independent related factors of AR.3.Bilirubin may become a predictor of AR in the future. |
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