Coronary Heart Disease Clinical Risk Factors And TCM Syndrome Factor Distribution For Aspirin Resistance Studies

Objective:To provide the evidence for prevention and treatment of aspirin resistance by analysing the prevalence and related risk factors and the TCM syndrome factor distribution of aspirin resistance in patients with coronary artery disease(CAD).Methods:One hundred patients aged(68.95±8.91)years with CAD who had received daily aspirin therapy(100 mg,1/n)at least 4 weeks and was confirmed by angiography were recruited.The effect of aspirin was assessed using the Platelet aggregation assay induced by AA(arachidonic acid).Aspirin resistance was defined as ? 80%,the definition of Aspirin semiresponders was<80%and ? 50%,aspirin sensitive was defined as<50%.On the base of literature materia and experts advice,decide the TCM syndrome factors(qi deficiency?sputum turbid?blood-stasis?qi stagnation?Yang deficiency?Yin deficiency?cold stagnation)of every patients.Risk factors and TCM syndrome factor were observed.Results:12 CAD patients were found to be resistant to aspirin therapy;Aspirin resistance in patients with the fasting blood glucose levels,creatinine,lesions in the coronary artery and severe lesion number higher than other groups(P<0.05);2 h after meal insulin levels low(P<0.05);The distribution of three groups in TCM syndrome factors was no statistical difference(P>0.05);In the multivariate logistic regression analysis,fasting serum glucose level was a significant risk factor of aspirin resistance.Conclusion:A significant number of patients with CAD are resistant to aspirin therapy.Fasting blood glucose level is closely associated with aspirin resistance in CAD patients;Aspirin sensibility has no effects on TCM syndrome factors distribution.