Study On The Association Between Serum Amyloid A And Carotid Atherosclerotic Plaques In Patients With Obstructive Sleep Apnea-Hypopnea Sydrome

Objective: The purpose of this study was to investigate the correlation between carotid atherosclerosis and serum amyloid A in OSAHS patients by studying serum amyloid A levels in OSAHS patients.Methods: The subjects were OSAHS patients who were diagnosed after receiving polysomnotic monitoring in affiliated hospital of Qinghai university from November 2016 to January 2020 and the healthy control group.The diagnosis of OSAHS was in line with the guidelines for the diagnosis and treatment of obstructive sleep apnea hyper ventilation syndrome(revised in 2011 by the Chinese medical association).According to the inclusion and exclusion criteria,120 patients were finally enrolled and they were divided into the control group(29(AHI < 5),the mild OSAHS group(26(5?AHI < 15),the moderate OSAHS group(27(15 ?AHI < 30),and the severe OSAHS group(38(AHI ?30)according to Apnea hypopnea index(AHI).Fasting blood was extracted from all the selected subjects for routine blood test,inflammatory factors,biochemical indicators and improvement of carotid color doppler ultrasound.General data,blood biochemical indicators,carotid intima media thickness and other data were collected.Finally,SPSS25.0 software was used for statistical analysis of the collected data.Results: 1.There was no significant difference in general data between the control group and the case group in Age,Sex,TC,LDL,Cr,Ur and CRP(P>0.05).2.BMI of the OSAHS group was higher than that of the control group,and TG,UA,SAA and CIMT were significantly higher than that of the control group(P < 0.01).There were differences in SAA and CIMT of the mild and severe OSAHS group.3.The HDL of the OSAHS group was lower than that of the control group,and Mini Sp O2 was significantly lower than that of the control group(P<0.01);4.After the bivariate correlation analysis,it was found that CIMT had a positive correlation with TG,a significant positive correlation with age,UA,CRP,SAA and AHI.(r= 0.467 P<0.001),a negative correlation with HDL,and a significant negative correlation with Mini Sp O2(r=-0.561 P<0.001).SAA level was positively correlated with CRP,AHI,UA and TG,and negatively correlated with HDL and Mini Sp O2.Conclusion: 1.this study confirmed that SAA levels are elevated OSAHS group,also obvious thickening of CIMT;2.The CIMT level is relative to the factors which include Age,TG,UA,CRP,AHI,SAA,HDL and Mini Sp O2;3.SAA level showed a significant positive linear correlation with CRP,AHI,UA and TG,and a significant negative linear correlation with HDL and Mini Sp O2,The results shows that SAA may be an important participant in the occurrence of arteriosclerosis in OSAHS.