Study On The Relationship Between High Density Lipoprotein And Coronary Atherosclerosis In Postmenopausal Women

Objective: To explore the correlation between the serum levels of high density lipoprotein cholesterol(HDL-C)and high density lipoprotein particles(HDL-P)and the degree of coronary atherosclerosis in postmenopausal women.Methods: According to the set standard,107 peri-menopausal and postmenopausal women who underwent coronary angiography because of palpitation,chest tightness,chest pain and other chest discomfort symptoms in the unify affiliated Krankenhaus of Qinghai College from November 1,2018 to January 1,2020 were choosed.According to the different menopausal time of the selected patients,We divided all the patients into three different groups : menopausal time < 5 years(n = 33),menopausal time 5-10 years(n = 36)and menopausal time >10 years(n = 38).The relationship between HDL-C,HDL-P,nationality,LDL and other related biochemical indexes and SYNTAX score were compared among the three groups.Results: A total of 107 women were included in the study,with an average age of 58.2 ±5.7year.It was found that there were no significant differences in low density lipoprotein(LDL),total cholesterol(TC),triglyceride(TG),hypertension,diabetes,body mass index(BMI),smoking,drinking and nationality among the three groups with menopausal time <5 years,menopausal time 5-10 years and menopausal time> 10 years.However,there were significant differences in HDL-C,HDL-P and age among the three groups.Therefore,Pearson correlation analysis showed that there was a positive correlation between HDL-C(r = 0.23,P <0.01)and age(r = 0.24,P < 0.05)and SYNTAX score,while a negative correlation between HDL-P(r = 0.3,P <0.01)and SYNTAX score.Therefore,compared with HDL-C,HDL-P is the real factor against coronary atherosclerosis in postmenopausal women.Conclusion: For postmenopausal women,high density lipoprotein cholesterol(HDL-C)is positively correlated with the degree of coronary arteriosclerosis,but total high density lipoprotein particles(HDL-P)are negatively correlated with the degree of coronary artery atherosclerosis,which still has anti-atherosclerotic effect.