| Objective The correlation between serum homocysteine and uric acid levels in patients with lacunar cerebral infarction and osteoporosis was investigated.It provides certain clinical guidance for early screening of osteoporosis in patients with lacunar cerebral infarction and is helpful to determine treatment strategies and prevent the progression of osteoporosis.Methods A total of 171 patients admitted to the department of geriatrics,affiliated hospital ofqinghai university from November 2018 to December 2019 were randomly selected.In combination with clinical and imaging examinations,lacunar cerebral infarction was definitely diagnosed,and whole-body bone mineral density measurement was completed within 1 week after admission.According to the T value of bone mineral density,it was divided into the lacunar cerebral infarction group(group A),lacunar cerebral infarction group with low bone mass(group B),and lacunar cerebral infarction group with osteoporosis(group C).The rest are grouped according to research needs.Collect patient case data,analyze and compare the general condition and clinical index.SPSS22.0 software was used for statistical description.Results(1)comparison of general data: age,gender,height,weight,there were statistical differences between groups(P<0.05).The mean age of patients in the osteoporosis group was higher than that in the low bone mass group and the simple lacunar infarction group.There was no significant difference in smoking history,hypertension history and diabetes history between the groups(P>0.05).(2)Hcy level was the highest in the group with osteoporosis,and gradually increased with the decrease of bone density.The concentration of TC in the group with osteoporosis and the group with low bone mass was higher than that in the group with simple lacunar infarction.There was no significant difference in SBP,DBP,AST,ALT,BUN,Cr,UA,TG,HDL-Camong the three groups(P>0.05).(3)Multivariate analysis showed that there was no statistical difference in the occurrence of osteoporosis among weight,TC,UA and ALP(P>0.05).Age,sex and Hcy level were statistically significant in the occurrence of osteoporosis(P<0.05),all of which were risk factors.(4)Correlation of bone mineral density in different parts: the correlation between age,weight,height,UA,Hcy,TC and bone mineral density in different parts of lacunar cerebral infarction patients was statistically significant(P<0.05).Age,body weight and Hcy were all influencing factors of bone mineral density at different sites.(5)The bone mineral density of menopausal women in different parts was lower than that of men,and the difference was statistically significant(P<0.05).There was no difference in bone mineral density in different parts of male patients(P>0.05).There were statistically significant differences in bone mineral density between different sites in menopausal women(P<0.05).(6)The relationship between bone mineral density in different parts and different age groups in males: the differences in BMDT values at lumbar Total,femoral neck,hip and 1/3 of forearm in different age groups were statistically significant(P<0.05).There was no statistically significant difference in BMDTvalues of lumbar spine,femoral neck,hip and forearm at 1/3 of different sites in the same age group(P>0.05).(7)The relationship between bone mineral density in different parts of women and age group: comparison among groups of different age groups: BMD T value at lumbar Total,femoral neck,hip and 1/3 of forearm showed statistical differences(P<0.05).Intra-group comparison: there was no statistical difference in BMD T values of lumbar spine,femoral neck,hip and forearm at 1/3(P>0.05)in 60 ?,70 ? age group.The difference of BMD T value between lumbar spine and femoral neck and hip group was statistically significant(P<0.05)in 80 ?.The difference of BMD T value between forearm 1/3 and femur femoral neck and hip group was statistically significant(P<0.05).Conclusion(1)Hcy is an independent risk factor for osteoporosis in patients with lacunar cerebral infarction.(2)Age and Hcy are the influencing factors of bone mineral density in different parts of patients with lacunar cerebral infarction.(3)Postmenopausal women are more likely to develop osteoporosis than men.In postmenopausal women,bone mineral density in the lumbar spine,femoral neck,and forearm by a third is more likely to be affected. |
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