Application Of Progestin Primed Ovarian Stimulationregimen In Patients With Low IVF Ovarian Reserve

Objective: To analyze the application value of Progestin primed ovarian stimulation(PPOS)in in vitro fertilization(IVF)patients with Diminished ovarian reserve(DOR),which is a clinical ovulation induction program.Develop a reference basis.Methods: From September 2016 to June 2019,the study time interval was selected.115 cases of DOR patients receiving IVF assisted pregnancy treatment and using PPOS ovulation induction program were selected as the case group in the Reproductive Medicine Center of Qinghai Provincial People's Hospital.135 patients with DOR who received progestation therapy and non-PPOS(micro-stimulation)ovulation induction program were used as control group.The general data of the two groups are shown in Table 1,and the baseline data are similar(P>0.05).Gn days,Gn dose,h CG injection day and trigger day of reproductive hormone(FSH,E2,progesterone P)levels,early onset LH peak rate,cycle cancellation rate,egg acquisition and embryo development(quality)were collected.Follicle number,number of eggs obtained,number of mature eggs,available embryos,fertilization rate,high quality embryo rate),clinical outcomes(planting rate,clinical pregnancy rate,ectopic pregnancy rate,abortion rate),clinical expenses(drug costs,B-ultrasound)Related data such as cost,laboratory and surgery costs,total cost,etc.,based on comparative analysis to explore the clinical application value of PPOS ovulation induction program.Results:(1)The Gn time of the case group was shorter than that of the control group,and the total amount of Gn was lower than that of the control group.The difference was statistically significant(P<0.05).(2)The E2 level of the h CG injection day and the trigger day of the case group was higher than that of the control group,and the progesterone P and LH were lower than the control group,and the difference was statistically significant(P<0.05).(3)The LH peak rate and cycle cancellation rate(6.09%,2.61%)in the case group were lower than those in the control group(17.04%,10.37%),and the difference was statistically significant(P<0.05).(4)The number of high-quality follicles and the number of eggs obtained in the case group were similar to those in the control group(P>0.05).The number of mature eggs,the number of available embryos,the rate of fertilization and the quality of embryos in the case group were higher than those in the control group.Significance(P<0.05).(5)The implantation rate and clinical pregnancy rate of the case group were higher than the control group,and the ectopic pregnancy rate and abortion rate were lower than the control group,and the difference was statistically significant(P<0.05).(6)The drug cost,B-ultrasound cost,laboratory and surgical cost,and total cost of the case group were lower than the control group,and the difference was statistically significant(P<0.05).Conclusion: PPOS ovulation induction scheme has more application advantages than micro-stimulation scheme,which can improve ovarian response,short Gn time,low dosage,high E2 water level,low progesterone P and LH,early LH peak rate and period cancellation.The rate is low,the quality of the egg and embryo is high,the clinical outcome is good,the pregnancy rate is high,and the clinical cost is low,which has good economic value.