Correlation Between Elevated Serum TGF-?₁ Concentration And Intraoperative Adverse Cardiovascular Events In Patients With Type 2 Diabetes

Objective:The study aims to investigate the correlation between increased serum TGF-?₁concentration and intraoperative adverse cardiovascular events in patients with type 2diabetes.Methods:Ninety-four patients undergoing elective knee arthroplasty under spinal anesthesia were assigned to diabetes group?DM group,n=29?,diabetic peripheral neuropathy group?DPN group,n=34?and non-diabetes group?NDM group,n=31?.The patients ranged in age from 50 to 79 years,and were not limited to men and women,ASA?-?.Preoperative serum TGF-?₁ concentrations were measured using enzyme-linked immunosorbent assay.The incidence of adverse cardiovascular events in three groups was monitored and recorded.Then we analyzed the correlation between serum TGF-?₁concentration and intraoperative adverse cardiovascular events in diabetic patients.Results:The serum TGF-?₁ levels in all diabetic patients were significantly higher than the non-diabetic patients?P<0.05?,but the serum TGF-?₁ was significantly higher in diabetic neuropathic patients than those without peripheral neuropathy?P<0.05?.The incidence of intraoperative adverse cardiovascular events and the serum TGF-?₁ concentrations in the NDM group,DM group and DPN group presented a consistent order as NDM group<DM group<DPN group,with the differences showing statistical significance?P<0.05?.When included in the overall comparison of cases,the concentration of TGF-?₁ in patients with adverse cardiovascular events was significantly higher than that in patients without adverse cardiovascular event?P<0.05?.Further intra-group comparison showed that in DPN group the concentration of TGF-?₁ in patients with adverse cardiovascular events was significantly higher than that without adverse cardiovascular events?P<0.05?.However,there was no statistical difference in both DM group and NDM group?P>0.05?,when making intra-group comparisons.Conclusion:Diabetes mellitus,diabetic peripheral sensory neuropathy and intraoperative adverse cardiovascular events were all significantly correlated with increased serum TGF-?₁.The mechanism underlying of the pathology is worthy to study.