Correlation Between Elevated Serum TGF-β₁ Concentration And Intraoperative Adverse Cardiovascular Events In Patients With Type 2 Diabetes

Objective:The study aims to investigate the correlation between increased serum TGF-β₁concentration and intraoperative adverse cardiovascular events in patients with type 2diabetes.Methods:Ninety-four patients undergoing elective knee arthroplasty under spinal anesthesia were assigned to diabetes group（DM group,n=29）,diabetic peripheral neuropathy group（DPN group,n=34）and non-diabetes group（NDM group,n=31）.The patients ranged in age from 50 to 79 years,and were not limited to men and women,ASAⅡ-Ⅲ.Preoperative serum TGF-β₁ concentrations were measured using enzyme-linked immunosorbent assay.The incidence of adverse cardiovascular events in three groups was monitored and recorded.Then we analyzed the correlation between serum TGF-β₁concentration and intraoperative adverse cardiovascular events in diabetic patients.Results:The serum TGF-β₁ levels in all diabetic patients were significantly higher than the non-diabetic patients（P<0.05）,but the serum TGF-β₁ was significantly higher in diabetic neuropathic patients than those without peripheral neuropathy（P<0.05）.The incidence of intraoperative adverse cardiovascular events and the serum TGF-β₁ concentrations in the NDM group,DM group and DPN group presented a consistent order as NDM group<DM group<DPN group,with the differences showing statistical significance（P<0.05）.When included in the overall comparison of cases,the concentration of TGF-β₁ in patients with adverse cardiovascular events was significantly higher than that in patients without adverse cardiovascular event（P<0.05）.Further intra-group comparison showed that in DPN group the concentration of TGF-β₁ in patients with adverse cardiovascular events was significantly higher than that without adverse cardiovascular events（P<0.05）.However,there was no statistical difference in both DM group and NDM group（P>0.05）,when making intra-group comparisons.Conclusion:Diabetes mellitus,diabetic peripheral sensory neuropathy and intraoperative adverse cardiovascular events were all significantly correlated with increased serum TGF-β₁.The mechanism underlying of the pathology is worthy to study.