Clinical Study On The Detection Of Various Trace Elements In The Pathogenesis Of Preeclampsia

Objective The contents of calcium,magnesium,copper,zinc,iron and serum 25 hydroxyvitamin D3 [25(OH)D3] in patients with preeclampsia and normal pregnant women were detected in order to analysis the relationship between the trace elements and the mechanism of preclapsia and provide the theoretical basis for the prevention of preeclampsia and the guidance of reasonable nutrition in pregnancy.Methods 50 pre-eclampsia pregnant women and 50 severe pre-eclampsia pregnant women,who underwent antenatal care in the Department of Obstetrics and Gynecology,Ningxia Hui Autonomous Region People's Hospital from June 2018 to October 2019 were selected as the case group.100 normal pregnant women were adopted as the control group.Flame atomic absorption method was applied to detect the content of trace elements calcium,magnesium,copper,zinc,and iron in pregnant women.Chemiluminescence immunoassay was conducted to detect the serum 25(OH)D3 content in pregnant women,and a comparative study was performed.Results(1)Baseline data: there were no statistically significant differences in the age,gestational week,and BMI among the normal pregnancy group,the preeclampsia group and the severe preeclampsia group(P >0.05).(2)The average value of copper in the case group was(26.31 ± 6.51)umol / L,which was higher than that in the normal pregnancy group(22.65 ± 4.31)umol / L,P = 0.000 <0.05,and the difference was statistically significant.The mean zinc element in the case group was(87.51 ± 12.68)umol / L,which was lower than that in the normal pregnancy group(98.28 ± 12.45)umol / L,P = 0.000 <0.05,and the difference was statistically significant.The average value of calcium in the case group was(1.49 ± 0.15)mmol/L,which was lower than [1.54(0.23)] mmol/L in the normal pregnancy group,P = 0.001 <0.05,and the difference was statistically significant.The average of magnesium in the case group was [1.31(0.15)] mmol/L,which was not significantly different from that of the normal pregnancy group [1.33(0.22)] mmol/L(P = 0.220> 0.05).The average iron content in the case group was(7.98 ± 0.93)mmol/L,which was higher than [7.11(0.80)] mmol/L in the normal pregnancy group,P = 0.000 <0.05,and the difference was statistically significant.The average value of 25(OH)D3 in the case group was [11.50(5.67)] ng/ml,which was lower than that of the normal pregnancy group [17.15(10.25)] ng/ml,P = 0.000 <0.05,and the difference was statistically significant.(3)The average value ofcopper in the severe preeclampsia group was(28.28 ± 6.20)umol / L,which was higher than that in the preeclampsia group(24.89 ± 5.78)umol / L,P = 0.002 <0.05,the difference was statistically significant.The mean value of zinc in the severe preeclampsia group was(83.88± 12.05)umol / L,which was lower than that in the preeclampsia group(91.34 ± 12.22)umol / L,P = 0.002 <0.05,and the difference was statistically significant.The mean value of zinc in the severe preeclampsia group was(1.44 ± 0.16)umol / L,which was lower than that in the preeclampsia group(1.53 ± 0.12)umol / L,P = 0.005 <0.05,and the difference was statistically significant.The mean value of magnesium in the severe preeclampsia group was(1.31 ± 0.11)mmol/L,which was not significantly different from the preeclampsia group(1.32 ± 0.11)mmol/L(P =0.467> 0.05).The average value of iron in the severe preeclampsia group was(8.17 ±0.91)mmol/L,which was higher than that in the preeclampsia group(7.79±0.91)mmol/L,P=0.036 <0.05,the difference was statistically significant.The average value of 25(OH)D3 in the severe preeclampsia group was(9.86 ± 3.41)ng/ml,which was lower than that in the preeclampsia group(13.65 ± 4.08)ng/ml,P = 0.000 <0.05,and the difference was statistically significant.(4)The contents of trace elements copper and iron in maternal whole blood were positively correlated with the severity of preeclampsia(r=0.349,P=0.000<0.05;r=0.416,P=0.000<0.05).The content of zinc,calcium,25(OH)D3 was negatively correlated with the severity of preeclampsia(r=-0.428,P=0.000<0.05;r =-0.280,P=0.000<0.05;r=-0.590,P=0.000<0.05).There was no correlation between magnesium content and the severity of preeclampsia(r=-0.104,P=0.143>0.05).Conclusion The level of trace elements calcium,zinc,and serum 25(OH)D3 were decreased and copper and iron in whole blood were increased in preeclampsia pregnant women compared to the control group,which suggests the change of the trace elements are related to the onset of preeclampsia,but the change of magnesium in the whole blood is no relationship with the onset of preeclampsia.