Research On Laser Welding Process And Thermal Damage Model Of In-vitro Skin Tissue

In order to improve the stability and reliability of laser welding process of in-vitro skin tissue,and obtain the influence of laser process parameters on tissue incision performance and thermal damage,and quantify the relationship between laser process parameters and tensile strength and thermal damage parameters,based on the single factor test,the paper analyze the effects of welding parameters such as laser power and laser frequency on the incision fusion effect and tissue surface morphology of in-vitro skin tissue,and determine the range of laser power and laser frequency.The use of zigzag scanning and bovine serum albumin can effectively promote the fusion effect of in-vitro skin tissue.The RSM is used to design the experiment,and the optimized model of process parameters for in-vitro skin tissue is established,and the optimized process parameters are obtained.Through analysis of variance,significant factors affecting the tensile strength and peak temperature are obtained.The experimental results show that the established models can accurately describe the relationship between laser process parameters and tissue properties,and the tensile strength can reach 44.8N·cm^-2.Combined with the classical integral formula of thermal damage,the whole factor test method is used to establish the thermal damage model of in-vitro skin tissue,and the optimized process parameters are obtained.Through analysis of variance,the significant factors affecting the thermal damage are laser power and laser frequency.The experimental results show that the established thermal damage model can accurately describe the relationship between thermal damage parameters and laser process parameters.With optimized process parameters,irreversible thermal damage will not occur in isolated skin tissue,and the tensile strength will meet the requirements.