Thlamus Functional Parcellation Based On Brain Connections

Thalamus is one of the most important structures in the human brain.It regulates the transmission of sensory and motor signals in the brain region.In addition,it is closely related to the regulation of consciousness,sleep and alertness.At present,a series of studies have shown that some neurological disease s can cause changes in the structure of the thalamus,such as Alzheimer disease(AD),anterior dorsal nucleus,Parkinson's disease(PD),subthalamic nucleus,schizophrenia,dorsomedial nucleus,epilepsy and anterior nucleus.These diseases can be treated surgically by targeting the thalamic nucleus.Deep Brain Stimulation(DBS)is a means of stimulating the thalamic cortical nerve pathway to restore neurological functio n.However,the accurate location of the thalamic nucleus is needed to determine the surgica l target.Traditional methods use anatomical atlas as a template,but individuals have differences.The specific location of the thalamic nucleus is different.The location,size and shape of thalamic nuclei vary from person to person.Therefore,the use of anatomical atlas as a template for the localization of thalamic nuclei in vivo has great limitations.In this paper,a method of thalamic Functional Regionalization Based on brain connection is designed.Thalamus subarea is a process of unsupervised clustering of thalamic voxels.Firstly,DTI(Diffusion Tensor Imaging)is used to track the fibers to obtain the structural connectivity information of the living brain.Secondly,in view of the complex and non-linear structural connectivity features of thalamic cortex,this paper uses the hidden subspace mapping of deep subspace network learning features.Finally,spatial constraints on voxel features can reduce the impact of noise,better reflect the spatial topology,enrich the extraction of spatial information,and facilitate the effective clustering of thalamic voxels.The purpose of this study is to study the functional division of thalamus in vivo based on diffusion tensor imaging(DTI).Based on the results of individual thalamic functional zoning,the group thalamic zoning map was constructed.Considering the individual differences,this paper discusses the validity of the zoning map and the superiority of the method at the group level.To verify the validity of the atlas,the functional and structural links between nuclei and cortex were validated in this paper.In order to verify the superiority of the research method,this paper uses two indicators of reproducibility and functional consistency to carry out comparative experiments,and examines the influence of parameters in clustering algorithm on the performance of the algorithm.The experimental results show that this method can effectively divide the thalamic function in vivo,and it has obvious advantages over the classical method of dividing the thalamus.