Study On The Distribution Characteristics Of Pathogenic Bacteria In Different Severity Grades Of Diabetic Foot Recurrent Infection

Objective To study the distribution characteristics of pathogenic bacteria in diabetic foot recurrent infection mellitus with different severity grades,and to provide the basis for the empirical treatment of diabetic foot infection.Methods A total of 184 cases of diabetic foot patients hospitalized between July 2016 and July 2018 were selected,among which 52 cases of recurrent infection were secreted by bacteria culture and drug sensitivity analysis.The severity of infection was analyzed and the relationship between infection severity and distribution of pathogenic bacteria was statistically analyzed.Results A total of 70 pathogenic bacteria were cultured in 52 patients with recurrent diabetic foot infection,among them,34 strains(48.57%)were gram-positive,and the top three strains were staphylococcus aureus,enterococcus faecalis and streptococcus aureus.Among 29 strains of gram-negative bacilli(41.43%),the top three were e.coli,proteus and klebsiella pneumoniae and 7 fungal strains(10.0%);among which the pathogenic bacteria were isolated from patients with severe recurrent infection and were resistant to most antibiotics,Gram-positive bacteria are more sensitive to vancomycin and have low drug resistance.Gram-negative bacteria are more sensitive to carbapenems such as ertapenem and have low drug resistance,all the 7 isolated fungi were candida albicans,which had high drug resistance to fluconazole and were sensitive to carbophenazim and amphotericin B.Among the 52 patients with recurrent diabetic foot infection,there were 19 cases of mild infection,20 cases of moderate infection and13 cases of severe infection.That is,with the aggravation of the severity of infection,the distribution of pathogenic bacteria was mainly from gram-positive mycococcus infection to gram-negative bacilli infection,and the test results showed that the difference was statistically significant(P<0.05).Single infection accounted for 89.47%of patients with mild recurrent infection and 10.53% of patients with mixed infection.The single infection accounts for 53.85% in patients with severe recurrent infection,and the mixed infection accounts for 46.15%.Trend test was performed for different infection types,and the difference was statistically significant(P<0.05),With the aggravation of disease severity,the type of infection changed from single pathogen to mixed conditioned pathogen.Conclusion With recurrence of diabetic foot infection degree aggravating,the pathogenic bacteria by gram-positive cocci infection rate decreased,gram negative bacillus infection ratio increases,the degree of infection is heavier,the higher the mixed infection opportunity,patients with severe infection recurrence to conventional antimicrobial agents have certain resistance,in the clinical treatment of diabetic foot strict control over the use of antimicrobial agents.If diabetic foot is associated with fungal infection,routine antifungal drugs may be of limited use.