Distribution And Antibiotic Resistance Of Pathogens In 125 Diabetic Foot Infection

Objective:To investigate distribution and antibiotic resistance of pathogens isolated from the patients with diabetic foot infection wounds in the First Affiliated Hospital of Fujian Medical University.Materials and Methods:Secrection taken from the 125 patients with diabetic foot infection wounds from January 2005 to December 2009 in the First Affiliated Hospital of Fujian Medical University,and send the sample in Aseptic test tube within 1 hour for the bacterial culture.The distribution and drug resistance of pathogenic bacteria were analyzed.Results:1)Altogether 119 strains of pathogens were isolated from 125 major samples, including 68 gram-negative strains(57.14%),41 gram-positive strains(34.45%)and 10 fungus strains(8.40%).The common pathogenic bacteria were Staphylococcus(17.65%),Enterococcus(14.29%),Pseudomonas aeruginosa(11.76%), Escherichia coli(10.92%), Proteus(10.92%),other are Klebsiella pneumoniae, Enterobacter cloacae, Morganella morganii, A. baumanii,α-Hemolytic streptococcus,and so on. And the mix infected person is 24 examples, accounts for 19.2%.2)The result of drug sensitivity showed the resistant rates of Gram-negative strains to meropenem,Imipenem and Amikacin Sulfate is less than 6%.In this study gram-negativ strains were highly resistants to Tetracycline,Compound Sulfamethoxazole, Ticarcillin and gentamicin (>40%). The result of drug sensitivity showed the resistant rates of gram-Positive strains toβ-lactams and quinolones is less than 10%.While highly resistants to the Penicillin,Oxacillin , Aminoglycosides , macrolides antibiotics , Tetracycline and sulfa drugs. Those who are worth the special attention is, the resistant rates of gram-Positive strains to Vancomycin and Teicoplanin is Between 12-18%.Conclusion:1)Gram negative strains remains the common in wounds of diabetic foot infection.Because of the absence of anaerobic bacteria culture in this experiment, it has not been unable to give the related data. 2)The result of drug sensitivity showed the resistant rates of gram-Positive strains toβ-lactams and quinolones is less than 10%.While highly resistants to the Penicillin,Oxacillin , Aminoglycosides , macrolides antibiotics , Tetracycline and sulfa drugs.The result of drug sensitivity showed the resistant rates of Gram-negative strains to carbapenem antibiotics is low.In this study gram-negativ strains were highly resistants to Tetracycline,Compound Sulfamethoxazole, Ticarcillin and gentamicin. 3)the resistant rates of gram-Positive strains to Vancomycin and Teicoplanin is Between 12-18%.4)In order to abase or prevent the increasing resistance of bacteria, Should need prompt, repeatedly Bacilliculture and drug sensitivity,optimal use of antibiotic.