Clinical Characteristics Of Eosinophilic And Non-eosinophilic Chronic Sinusitis With Nasal Polyps

Objective: Chronic rhinosinusitis(CRS)is a common disease,which seriously affects the quality of life of patients.CRS is a multifactorial disease characterized by accumulation of inflammatory cells in the nasal cavity and sinuses,accompanied by tissue remodeling.According to the presence or absence of nasal polyps,it can be divided into two types: chronic rhinosinusitis with nasal polyps(CRSwNP)or chronic rhinosinusitis without nasal polyps(CRSsNP);because some of the pathological changes of CRS nasal polyps.Eosinophilic infiltration is one of the main pathological features,and it can be divided into two subtypes: eosinophilic(EOS CRSwNP)and non-eosinophilic(NONEOS CRSwNP).They may be different in clinical characteristics,pathogenesis,therapeutic effect and prognosis.This study will classify the clinical characteristics of EOS CRSwNP and NONEOS CRSwNP.Analysis and comparison in order to adopt more targeted treatment strategies or methods for different subtypes in the future and improve the therapeutic effect.Methods: 92 patients with chronic sinusitis with nasal polyps were collected and divided into eosinophilic chronic sinusitis with nasal polyps(EOS CRSwNP)and non-eosinophilic chronic sinusitis with nasal polyps(NONEOS CRSwNP)by pathological classification.Comparisons were made among demographic data,eosinophil ratio in peripheral blood,pathology,clinical symptoms,endoscopic sinus examination,Lund-Mackay score of CT.Results: In northern Fujian,there was no significant difference in age and sex distribution between EOS CRSwNP and NONEOS CRSwNP(P > 0.05),while NONEOS CRSwNP was more common(84.8%).NONEOS CRSwNP had the following clinical characteristics: 1)most nasal discharge was purulent;2)more pyocysts can be seen in nasal polyps;3)the proportion of eosinophils in the peripheral blood was mostly normal.4)mainly maxillary sinus lesions.EOSCRSwNP had the following characteristics: 1)most nasal discharge was mucous purulent;2)bilateral sinus lesions were more common,mainly ethmoid sinus lesions.3)the proportion of blood eosinophilic cells in peripheral blood was often increased.Conclusion: there are differences in clinical characteristics between eosinophilic and non-eosinophilic chronic sinusitis with nasal polyps.The ratio of eosinophils in peripheral blood,preoperative endoscopy and CT evaluation are helpful for the classification of chronic sinusitis with nasal polyps,According to these clinical characteristics,it can provide more targeted treatment for patients with chronic sinusitis and nasal polyps,and can more accurately judge the prognosis of patients,and facilitate communication with patients.