Association Between Susceptibility Gene Polymorphism And Genetic Susceptibility To Lung Cancer

Objective: To explore the relationship between PGC gene polymorphism and genetic susceptibility of lung cancer.Method: 419 lung cancer patients from Union Medical College Hospital affiliated to Fujian Medical University were selected as observation group,459 non-cancer patients were collected as control group,and SNPs of PGC-1a gene were screened for detection,to explore the correlation between susceptibility gene loci and genetic susceptibility of lung cancer.Result:(1)Smoking,drinking and body mass index(BMI)are risk factors for lung cancer.(2)Gly482Ser(rs8192678)locus had no significant correlation with lung cancer.(3)The frequency of Allele 1 in Thr612Met(rs3736265)was 0.827/0.864 in case group and control group respectively(P < 0.05),indicating that A allele in case group became G allele,which significantly increased the risk of lung cancer.By unconditional logistic regression analysis,we found that the GA allele rs3736265 significantly increased the risk of lung cancer.The OR value was 1.446(95% CI: 1.065-1.961).After adjusting for gender,age,BMI,smoking status and drinking status,the OR value was 1.408(95% CI: 1.020-1.945).At the same time,we found that GA allele increased the risk of lung cancer with OR value of 1.436(95% CI: 1.060-1.946)and adjusted OR value of 1.392(95% CI: 1.009-1.920).By stratified statistical analysis and unconditional logistic regression,we found that adenocarcinoma was more likely to occur when the A allele of this locus became G allele(P < 0.05).In addition,we found that in patients younger than 60 years old,the risk of lung cancer in type GA was 1.772 times higher than that in GG(95% CI: 1.085-2.894);in non-alcoholic patients,the risk of lung cancer in type GA was 1.492 times higher than that in type GG(95% CI: 1.068-2.085);and in people with BMI less than 24,the risk of lung cancer in type GA was 1.691 times higher than that in type GG(9.691 times).5% CI: 1.100-2.601).(4)Thr394Thr(rs2970847)is 4.098 times more likely than CC to develop lung cancer in patients over 60 years of age(95% CI: 1.264-13.282),suggesting that detection of this locus can predict the incidence of lung cancer in the elderly population.Conclusion:(1)Smoking,drinking and body mass index(BMI)are risk factors for lung cancer.(2)Gly482Ser(rs8192678)locus had no significant correlation with lung cancer.(3)The frequency of Allele 1 in Thr612Met(rs3736265)was 0.827/0.864 in case group and control group,respectively(P < 0.05),indicating that A allele in case group changed into G allele,which significantly increased the risk of lung cancer,mainly in adenocarcinoma.In patients younger than 60 years old,non-drinkers and people with BMI less than 24,the presence of A allele significantly increased the risk of lung cancer.(4)Thr394Thr(rs2970847)in patients over 60 years of age,the risk of lung cancer in TT allele was significantly higher than that in CC allele,suggesting that detection of this locus can predict the incidence of lung cancer in the elderly population.