Synthesis And Properties Of Lanthanide Metal Complexes Based On Ligand 1,4-Bis(Imidazol-1-yl) Terephthalic Acid

Metal complexes have great prospects in the fields of electromagnetic materials,biomedicine and photoelectric sensing because of their good biological activity and structure.They have been one of the most important research topics of scientific research workers.Cisplatin anti-cancer activity was discovered and used in clinical application in 1967,some groups continue to design and synthesize a series of novel structures of metal complexes,from which screening efficient,low toxicity,high selectivity of anti-cancer drugs.Because of its excellent fluorescence properties,lanthanide metal complex is a research hotspot.Imidazole polycarboxylic acid ligands have a variety of coordination groups,so they can coordinate with various metal ions through variety of ways,the coordination of polymer research has also been widely concerned by scholars.In this paper,lanthanide metal complexes with 1,4-Bis（imidazol-1-yl）terephthalic acid as the main ligand were studied.1、According to the principle of crystallography,the following 6 lanthanide metal complexes were successfully synthesized by hydrothermal method,and the single crystal was obtained.（1）[Pr₂(C₁₄H₉N₄O₂)（C₂O₄）₃（H₂O）₄]_n·6n（H₂O）（2）[Eu₂(C₁₄H₉N₄O₂)（C₂O₄）₃（H₂O）₄]_n·6n（H₂O）（3）[La(C₁₄H₈N₄O₂)（C₄H₄O₄）]_n（4）[Eu(C₁₄H₈N₄O₂)（C₂O₄）（H₂O）]_n·n（H₃O⁺）（5）[La₂(C₁₄H₈N₄O₄)₃（H₂O）₄]_n（6）[Pr₂(C₁₄H₈N₄O₄)₃（H₂O）₄]_n2、The structure of the complex was studied by X-ray diffraction analysis.The crystal structure of the complex was described.Wherein the complex 1 and the complex 2,the complex 5 and the complex 6 are hetero-isomorphous.3、The infrared spectra of the complexes and the main ligandwere tested and the IR spectra were analyzed.The fluorescence properties of the complex 1,complex2 and complex 4 were briefly studied.4、The inhibitory effect of complex 3 and complex 4 on HL60 cells and K562cells was detected by MTT assay.The results showed that the inhibitory effect of complexes on the cells was positively correlated,respectively.