Observation And Analysis Of Glucose And Lipid Metabolism In Young Men At Different Altitudes

Objective: To observe the changes of glycolipid metabolism related indexes and PGC1 a,Irisin,UCP1 levels of healthy people in the condition of acute hypoxia from plain area to sub plateau and plateau area,and to explore the characteristics of glycolipid metabolism and the effects of PGC1 a,Irisin and UCP1 on glycolipid metabolism in the environment of acute hypoxia at different altitudes,so as to provide reference for the health care of people in the plateau area.Methods: Thirty healthy young male enlisted soldiers were recruited from the plain area,starting from the 50 m altitude area(Nanning,Guangxi)to the 2100 m altitude area(Xining,Qinghai),and then two months later from Xining to the 3700 m altitude area(Guoluo,Qinghai).All the subjects collected general data and blood from elbow vein three days later(day 4 morning fasting)in 50 m altitude area,2100 m altitude area and 3700 m altitude area.According to the different altitude,the obtained data are divided into 50 m altitude group,2100 m altitude group and 3700 m altitude group.WBC,Neu%,HGB,RBC,FPG,TG,TC,HDL-C,LDL-C,FFA,PGC1 a,Irisin and UCP1 were measured in three groups.Blood lipid,blood glucose and other indexes were compared in three groups.The correlation between PGC1 a,Irisin and UCP1 and glycolipid metabolism was observed.SPSS23.0 software was used for data analysis.Results : 1.There were significant differences in body weight and waist circumference among the three groups(P < 0.05).There was no significant difference in BMI among the three groups(P > 0.05).2.There were significant differences in WBC and HGB among the three groups(P < 0.05);with the increase of altitude,WBC increased first and then decreased,HGB increased with the increase of altitude.There was no significant difference between the three groups in blood Neu% and RBC(P > 0.05).3.There were significant differences in TC,TG and FFA among the three groups(P < 0.05);with the increase of altitude,TG level gradually decreased,TC level first no significant difference in HDL-C and LDL-C among the three groups(P > 0.05).4.There was significant difference in FPG among the three groups(P < 0.05).With the increase of altitude,FPG level decreased gradually.5.There were significant differences in PGC1 a and UCP1 among the three groups(P < 0.05);with the increase of altitude,the levels of PGC1 a,Irisin and UCP1 decreased gradually.There was no significant difference in Irisin among the three groups(P > 0.05).6.Correlation analysis of PGC1 a,Irisin,UCP1 and glycolipid metabolism in young men at different altitudes: Irisin was positively correlated with TG(r = 0.402,P < 0.05)and negatively correlated with HDL-C(r = 0.386,P < 0.05)in 50 m altitude group.UCP1 level was positively correlated with TG(r = 0.403,P < 0.05).Irisin was positively correlated with TG(r = 0.397,P < 0.05).Conclusion: 1.Acute hypoxic environment can lead to the rise of HGB,the rise of WBC and the decline of body weight and waist circumference.2.Acute hypoxic environment has an effect on glucose and lipid metabolism,which can lead to the decrease of FPG,TG and TC.3.Acute hypoxia affects the PGC1a-Irisin-UCP1 pathway,which may be involved in regulating body fat metabolism.