Study On The Relationship Between Sleep Quality And C-reactive Protein,PCT And Vascular Endothelial Function In Patients With Hypertension

Objective: By studying the relationship between sleep quality and C-reactive protein,PCT and vascular endothelial function in patients with hypertension,we can provide evidence for improving the treatment and prognosis of patients with hypertension.Methods: A total of 100 patients with hypertension who were admitted to the Affiliated Hospital of Qinghai University from November 2018 to November 2019 were selected as the research subjects.They were divided into the normal sleep quality group(50 cases)and low sleep by the Pittsburgh Sleep Quality Index(PSQI).Quality group(50 cases).The gender,age,history of hypertension,family history,past history,and medication history of the two groups of subjects were collected separately.The Siemens BNII full-automatic specific protein analyzer was used to measure C-reactive protein,the PCT kit produced by Xitang Biotechnology(Shanghai)Co.,Ltd.was used to measure procalcitonin(PCT),and the ultrasonic vascular endothelial function tester(OMRON Medical Instruments Limited)Company)to measure brachial artery endothelial function(FMD).Statistical methods were used to compare the relevant indexes of the two groups of subjects.Results: In patients with hypertension,the score of vascular endothelial function(FMD)was higher in the normal sleep quality group than in the low sleep quality group(P <0.05).The sleep quality group with lower levels was higher(P <0.05);further binary logistic regression showed that sleep quality and FMD in patients with hypertension(? =-0.143,P = 0.008),cortisol(? = 0.325,P < 0.001)and high density lipoprotein(? = 2.227,P = 0.022).Conclusions: Sleep quality was not statistically different from C-reactive protein and PCT in patients with hypertension.FMD,cortisol,and high-density lipoprotein were factors that affected sleep quality.