Clinical Significance Of MUC1 Protein Expression In Non-small Cell Lung Cancer

Objective To investigate the expression of MUC1 protein in serum and cancer tissues of patients with different types of non-small cell lung cancer(non-small cell lung cancer,NSCLC),and to analyze the relationship between its expression level and the clinical characteristics of different types of NSCLC patients.Methods From December 2017 to December 2018,peripheral blood and lung tissues of 34 cases of lung squamous cell carcinoma,65 cases of lung adenocarcinoma and 20 non-lung cancer were collected from the General Hospital of Ningxia Medical University.The expression of MUC1 protein in serum was detected by enzyme-linked immunosorbent assay(ELISA).After HE staining confirmed that the lung tissue specimens met the pathological tissue type requirements,MUC1 protein expression was detected by immunohistochemical staining.Clinical value of MUC1 protein in serum for predicting different types of NSCLC patients by ROC curve analysis.Results The expression of MUC1 protein in serum and cancer tissues of patients with lung squamous cell carcinoma and lung adenocarcinoma was higher than that of non-lung cancer group(P<0.05).The optimum critical value of serum MUC1 protein in the diagnosis of lung squamous cell carcinoma was 33.23 U/mL,with a sensitivity of 52.94% and a specificity of 100%.The positive expression rates of MUC1 protein in serum and cancer tissues of patients with lung squamouscell carcinoma was not related to the difference of pathological differentiation,TNM clinical stage,age and sex(P>0.05).The optimal critical value of serum MUC1 protein in the diagnosis of lung adenocarcinoma was 31.31 U/mL,with a sensitivity of 61.54% and a specificity of 95%.The positive expression rates of MUC1 protein in serum and cancer tissues of lung adenocarcinoma patients with middle-low tissue differentiation and TNM clinical stage III-IV were higher than those of patients with high tissue differentiation and TNM clinical stage I-II(P<0.05).Conclusion MUC1 protein is highly expressed in NSCLC patients,which can be used for early clinical diagnosis and malignant degree evaluation of lung adenocarcinoma.MUC1 protein has limited significance in the early diagnosis and evaluation of lung squamous cell carcinoma.