The Optimal Drug Compatibility On The Use Of Postoperative Patient Controlled Intravenous Analgesia(PCIA) In Laparoscopic Urological Surgery

Objective:By observing and analyzing the effect of PCIA on Postoperative Analgesia,sedation,comfort and satisfaction of laparoscopic urology patients,the optimal postoperative PCIA scheme was selected.Methods:90 patients volunteering for PCIA after elective aparoscopic urological surgery were enrolled,and 3 groups were assigned according to the diverse drug compatibility of the PCIA,SFgroup(sufentanil 2.0ug/kg + fluorobiprofen 3.0mg/kg group,n=30)SD group(sufentanil 2.0ug/kg + dexmedetomidine 4.0ug/kg group,n=30),SFD group(sufentanil 1.0 ug/kg + fluorobiprofen 3.0mg/kg + dexmedetomidine 4.0ug/kg group,n=30).Dexamethasone 10 mg was used in each group.The postoperative pain visual analogue scale(VAS),Ramsay sedation score,Likert-5 grade score,BCS score,occurrence of adverse reaction as well as the number of pressing times of analgesic pump were respectively observed and recorded at 6 h,24 h and 48 h.Results:At 6h after operation,there was no significant difference in VAS score,BCS score and the number of times of analgesic pump compression among three groups(P > 0.05).The Ramsay sedation scores of SD group and SFD group were higher than that of SF group(P < 0.05),while no difference between SD group and SFD group(P > 0.05).The SFD group have witnessed lower incidence of adverse reaction and higher Likert-5 grade score when compared with SF group and SD group(P < 0.05),and there was no difference between the two indicators in SF group and SD group(P > 0.05).At 24 h after operation,there was no difference among the three groups with VAS score,BCS score,adverse reaction,and the number of times of analgesic pump compression.The Ramsay sedation scores and Likert-5 grade scores in SD and SFD groups were higher than those in SF group(P < 0.05),while no significant difference shown between the SD and SFD group(P > 0.05).At 48 h after operation,there was no significant difference in VAS score,Likert-5 grade score,BCS score,occurrence of adverse reaction,and number of times of analgesic pump compression among three groups(P > 0.05).The Ramsay sedation scores in SFD group and SD group were higher than that of SF group(P <0.05),there was no difference between SFD group and SD group(P > 0.05).No urinary retention,respiratory depression,disturbance of consciousness and other adverse reaction were observed in three groups.Conclusions:Better analgesia and sedation effect,higher comfort and satisfaction,and lower incidence of postoperative adverse reactions can be achieved in SFD group by a combination of sufentanil 1.0ug/kg,fluorobiprofen 3.0mg/kg and dexmedetomidine 4.0ug/kg.