The Signifcance Of FOXQ1 And CDK4 Expression In Papillary Thyroid Carcinoma

Objective:To investigate the expressions and clinical significances of forkhead box protein Q1(FOXQ1)and cyclin-dependent kinases 4(CDK4)in papillary thyroid carcinoma(PTC).Methods:The expression of FOXQ1 and CDK4 in 126 samples of PTC tissues and their adjacent normal tissues by immunohistochemistry En Vision method,and its relationships with clinical pathological features of PTC were analyzed.Results:1.The positive expression rates of FOXQ1 protein in PTC was significantly higher than those in corresponding adjacent normal tissues,and the difference is statistically significant(P<0.05).The positive expression rates of FOXQ1 protein was correlated with the lymph node metastasis and clinical stage(P<0.05),but no significant relationship with gender,age,tumor size was identified(P>0.05).2.The positive expression rates of CDK4 protein in PTC was significantly higher than those in corresponding adjacent normal tissues,and the difference is statistically significant(P<0.05).The positive expression rates of CDK4 protein was correlated with the lymph node metastasis and clinical stage(P<0.05),but no significant relationship with gender,age,tumor size was identified(P>0.05).3.The expression rates of FOXQ1 and CDK4 were positively correlated in PTC(P<0.05).Conclusion:The high expression of FOXQ1 and CDK4 may be related to the occurrence,development of PTC,and they may play an oncogenic role in PTC.