| Objective:Using resting brain functional magnetic resonance imaging technology to explore the changes of low frequency amplitude rate(fALFF)and local consistency(ReHo)in different brain regions of elderly patients with type 2 diabetes and mild cognitive dysfunction Changes in brain function activity at rest when the degree of cognitive function is impaired,and analysis of related metabolic indicators that affect the cognitive function of elderly T2 DM patients to provide clinical imaging evidence for early active intervention in the development of T2DM-MCI.Methods:According to the inclusion and exclusion criteria,due to the influence of head movement factors or the inability to cooperate with the head magnetic resonance examination and other factors,the age of ?60 years old who was treated in the geriatric department of the First Affiliated Hospital of Shanxi Medical University from July 2017 to July 2019 was finally selected 21 type 2 diabetes groups(T2DM group)and 20 healthy control groups(NC group)were taken as the research objects;the general clinical data and blood biochemical indicators of the included subjects were collected and evaluated by the Montreal Cognitive Assessment(MoCA)Beijing Scale Use statistical methods to compare the differences in cognitive function between the two groups of patients,and analyze the related factors of cognitive function in elderly patients with T2DM;use SPM and DPARSF software on the Matlab platform for image processing and statistical analysis to compare the T2 DM group Compared with the changes of fALFF and ReHo values in different brain areas of NC group,the changes of brain function activity in elderly patients with type 2 diabetes and mild cognitive impairment were investigated.Results:Comparison of cognitive function between T2 DM group and NC group: MoCA scale score results are expressed as mean ± standard deviation,T2 DM group(19.95±4.68)points,NC group(25.10±3.06)points,the difference between the two groups was statistically significant(P <0.05).Comparison of changes in brain functional activity between the T2 DM group and the NC group in resting state: The brain areas with higher fALFF values in the T2 DM group compared with the NC group include the right middle temporal gyrus,the right spindle gyrus,and the left middle temporal gyrus.The brain areas with weakened fALFF values included the right superior temporal gyrus,the right central cingulate gyrus,and the left superior temporal gyrus.The differences were statistically significant(P <0.05).The brain regions with increased ReHo values in the T2 DM group compared with the NC group include the right inferior temporal gyrus,the right inferior occipital gyrus,the left fusiform gyrus,the left anterior wedge,and the right fusiform gyrus.The brain regions with reduced ReHo values in the T2 DM group compared with the NC group include right upper frontal gyrus,right lower frontal gyrus,left middle temporal gyrus,left upper parietal gyrus,left posterior cingulate gyrus,left lower frontal gyrus,and left upper frontal gyrus.Statistical significance(P <0.05).The differences were statistically significant(P <0.05).Analysis of factors influencing cognitive function in the T2 DM group: No significant correlation was found between blood glucose,blood lipids,body mass index,glycated hemoglobin,diabetes course and cognitive function.Conclusion:Elderly patients with type 2 diabetes mellitus with mild cognitive impairment are mainly characterized by abnormal weakening and activation of brain functional activities in some temporal,frontal,and occipital regions,and may be damaged and compensated coexist.Abnormal changes in brain functional activity in different brain regions may explain that selective cognitive impairment may occur in elderly T2 DM patients with MCI. |
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