Resting State FMRi Study Of Abnormal Brain Function In Overweight With Type 2 Diabetes Mellitus Patients

Objective:To investigate the characteristics of brain function changes in overweight combined with type 2 diabetes mellitus patients on resting state.Methods:20 patients of overweight with type 2 diabetes mellitus(OW+T2DM),and20 patients of normal weight with type 2 diabetes mellitus(NW+T2DM)and 19 healthy controls(HC)were enrolled in this study.All the subjects completed a resting-state functional magnetic resonance imaging(rs-fMRI)examination and neuropsychological assessments.The differences of fALFF and ReHo values in brain area and neuropsychological scale were observed among the three groups.Results : Compared with healthy controls,OW+T2DM group showed decreased fALFF values in the right middle occipital gyrus,right inferior occipital gyrus,right middle temporal gyrus,bilateral calcarine,bilateral lingual gyrus and left cerebellum,and increased fALFF values in the left parahippocampal gyrus;NW+T2DM group showed decreased fALFF values in the right middle occipital gyrus and right calcarine gyrus.Compared with NW+T2DM group,OW+T2DM group showed decreased fALFF values in the left middle temporal gyrus and inferior temporal gyrus.Compared with healthy controls,OW+T2DM patients showed significantly decreased ReHo values in the right middle occipital gyrus/inferior occipital gyrus,left calcarine,left cuneus and left cerebellum,and while increased in the left insula;NW+T2DM patients showed significantly decreased ReHo values in the bilateral middle occipital gyrus/inferior occipital gyrus,bilateral calcarine gyrus,left lingual gyrus,left fusiform gyrus and left cerebellum.Compared with the NW+T2DM group,OW+T2DM patients showed significantly decreased ReHo values in the right middle frontal gyrus,right central anterior gyrus,and left cerebellum.There were no significant differences in the MMSE score,MOCA score,CDT and TMT-A test among the three groups.Conclusion:Overweight exacerbates the damage to brain function of patients with type 2 diabetes mellitus,which might mainly affected the temporal lobe(middle and inferior temporal gyrus)?frontal lobe(frontal middle gyrus,central anterior gyrus)andcerebellum.OW+T2DM Patients may exacerbate brain functional damage in regions related to executive control network.