Expression And Association Of TRAF4 In Esophageal Squamous Cell Carcinoma

Background According to epidemiological statistics,China is a high incidence area of esophageal squamous cell carcinoma,which is more common in men over 40 years old.As we known,the treatment of esophageal cancer is mainly due to early surgical treatment.But many patients often develop later in stages,with high morbidity and mortality,lost the opportunity for early surgery,and there is still no effective targeted therapy.Meanwhile,esophageal cancer is more common in adenocarcinoma in Europe and the Americas.Most studies on esophageal cancer in the world are mainly based on adenocarcinoma now.So,it is urgent to find new targets for the treatment of esophageal squamous cell carcinoma.TRAF4 has been regarded as a cause of carcinogenesis due to overexpression in many cancer types and participation in multiple signaling pathways.However,there are few studies on TRAF4 in ESCC worldwide.Its expression in ESCC and whether it affects the prognosis of patients still remains unclear.We hope that this experiment can be used to find potential therapeutic targets for esophageal squamous cell carcinoma.This will lay a foundation for further exploration of the occurrence and development mechanism of esophageal squamous cell carcinoma and the discovery of new therapeutic targets.Methods We detected the expressions of TRAF4,ki-67 and p53 by immunohistochemical technique in 100 cases of ESCC and 80 cases of adjacent normal tissues.The relationship between TRAF4 expression and clinicopathologic characteristics and prognosis were explored by Kaplan-Meier survival analysis and log-rank statistical test.Correlation analysis between the two variables was performed by using Spearman's rank correlation analysis,and multiple factors using Cox regression.Results TRAF4 was highly expressed in ESCC tissues and mainly expressed in the cytoplasm.Overexpression of TRAF4 in ESCC was also associated with high expression of ki-67 and p53(P < 0.05).We also found that patients with high expression of TRAF4 had significantly lower OS than patients with low TRAF4 expression(P < 0.05).Meanwhile,overexpression of TRAF4 was an independent risk factor affecting the prognosis of patients(P < 0.05).Conclusion We found that TRAF4 was highly expressed in ESCC tissues and mainly expressed in the cytoplasm of cancer cells.Overexpression of TRAF4 was an independent risk factor affecting the overall prognosis of patients.The results indicated that TRAF4 may become a new target for the treatment of ESCC in the future.