The Study On Correlation Between Coagulation Function And Clinical Features Of Lung Cancer Patients

Objective: The project was designed to analyze the distribution of peripheral blood coagulation function in discrepant clinical characteristics in lung cancer,to explore the risk factors of hypercoagulation status,and to provide a reference to prevent hypercoagulability and VTE for patients with lung cancer.Methods: The study recruited 587 cases with lung cancer from March 2012 to July 2018 at the first affiliated hospital of Fujian Medical University.Collected data contained the relevant indicators of coagulation function(PT,APTT,FIB,TT,D-D,PLT)at the time of diagnosis,gender,age,smoking history,pathological type,stage,whether with underlying diseases,the status of EGFR and ALK.Database was established and statistical analysis was conducted by SPSS 24.0.Median was described in measurement data,non-parametric was used in univariate analysis,and logistic regression in multivariate analysis.P<0.05 was regarded as statistical differences.Results: 1 Relationship between general condition and coagulation function in patients with lung cancer: univariate analysis displayed that coagulation indexes were different in individuals with different gender,age,smoking history,whether with underlying diseases(including infections,diabetes,hypertension,cardiac disease,hyperlipidaemia,other pulmonary disease,and nephropathy),pathological type,TNM stage of NSCLC,the status of ALK(P<0.05).There was no statistically significant difference between the coagulation function with imparity whether combined other malignancy,stage of SCLC and the status of EGFR.2 The risk factors of abnormal coagulation function in lung cancer: logistic regression statistical methods demonstrated that ?patients with infections was a risk factor for elevated PLT(OR=2.560,95%CI[1.510-4.340],P<0.001),FIB(OR=1.856,95%CI [1.164-2.959],P=0.009),and D-D(OR=1.969,95%CI [1.241-3.123],P=0.004)in lung cancer.Furthermore,squamous carcinoma was a risk factor for elevated PLT(OR=2.173,95%CI [1.012-4.666],P=0.047),and SCLC for increased D-D(OR=1.919,95%CI [1.008-3.653],P=0.047);?The terminal NSCLC patients show elevated PLT,FIB and D-D statistically(P<0.05).Conclusions: 1 The elevated PLT,FIB and D-D were primarily indicators in lung cancer with abnormal coagulation function.2 Coagulation indicators were statistically correlated with gender,age,smoking history,whether combining diseases(covering infections,diabetes,hypertension,cardiac disease,hyperlipidaemia,other pulmonary disease,and nephropathy),pathological type,TNM stage of NSCLC,the status of ALK in lung cancer.3 Concurrent infection and advanced lung cancer were risk factors for elevated PLT,FIB and D-D.