Correlation Between Etiological Analysis And Disease Severity In 112 Adult Patients With Bronchiectasis

Objective:With the development of high resolution computed tomography(HRCT),medical technology and economic development,people are paying more and more attention to bronchiectasis.Domestic and foreign guidelines have conducted extensive research and systematic classification of the etiology of bronchiectasis.However,little is known about the relationship between etiology and disease severity FACED scores.The FACED score includes: FEV1% pred(percentage of forced expiratory volume in one second)(F),age(A),Pseudomonas aeruginosa colonization(C),imaging findings(E),and medical research in the UK Medical research council dyspnea scal(MRC)(D).This study aims to explore the correlation between the etiology and disease severity of bronchiectasis.Methods:We collected 112 patients with bronchiectasis admitted to our hospital,Fujian Province from January 2016 to January 2018.All patients were identified as bronchiectasis by chest HRCT scan.Detailed medical history and physical examination were performed.The causes of the non-cystic fibrosis bronchiectasis were screened and comprehensively analyzed to determine the cause.According to the patient's age,lung function,Pseudomonas aeruginosa colonization,chest CT and the number of lungs,MRC to assess the severity of FACED,to explore the correlation between the etiology and disease severity of bronchiectasis.Results:This study included 112 patients,52 males(46.4%),60 females(53.6%),aged 18-83 years,mean age(61.0 ± 14.8)years old,including all infections including infection(30.4%)),idiopathic bronchiectasis(36.6%),chronic obstructive pulmonary disease(COPD)(15.2%),allergic bronchopulmonary aspergillosis(ABPA)(4.5%),Connective tissue disease(CTD)(8.9%),diffuse panbronchiolitis(1.8%),bronchial asthma(1.8%),and one Kartagener syndrome.The etiology of bronchiectasis after infection include tuberculosis,non-tuberculous mycobacteria,foreign bodies,aspiration,etc.,of which tuberculosis infection accounts for 47%. There was no statistically significant difference in the etiology between men and women.The severity of bronchiectasis disease is positively correlated with age,P.aeruginosa colonization,MRC,and the number of acute exacerbations requiring hospitalization in the past year.The severity of bronchiectasis disease and body mass index(BMI),FEV1% The predicted values were negatively correlated,both of which were statistically significant(P < 0.05).Smoking is a higher proportion in severe patients,but not statistically significant.Severe patients had the highest incidence of post-infection and COPD,accounting for 40.9% of the total(P<0.05).Pulmonary hypertension and emphysema with the increase of the severity of the disease,the proportion of which increases,suggesting that the two are closely related to the severity of the disease,often suggesting a poor prognosis.Conclusions: 1.In adult bronchiectasis,the most common causes are idiopathic and postinfectious bronchiectasis,chronic obstructive pulmonary disease.The cause of bronchiectasis after infection is mainly tuberculosis.2.Mild to moderate bronchiectasis,more common in idiopathic and post-infectious bronchiectasis;severe cases are more common in post-infectious bronchiectasis and chronic obstructive pulmonary disease.3.The severity of bronchiectasis disease is related to age,Pseudomonas aeruginosa colonization,MRC,number of acute exacerbations requiring hospitalization in the past year,FEV1% pred,BMI,pulmonary hypertension and emphysema are related to the severity of the patient.